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Comment
. 2022 Oct;8(10):785-787.
doi: 10.1016/j.trecan.2022.04.002. Epub 2022 Apr 22.

Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic

Oliver Kepp  1 , Guido Kroemer  2
Affiliations
Comment

Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic

Oliver Kepp et al. Trends Cancer. 2022 Oct.

Abstract

Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased immunosurveillance and response to checkpoint blockade.

Keywords: PARP; immunogenic cell death; immunotherapy.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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