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. 1987 Feb;7(2):639-49.
doi: 10.1128/mcb.7.2.639-649.1987.

Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells

K Nishikura, J M Murray

Antisense RNA of proto-oncogene c-fos blocks renewed growth of quiescent 3T3 cells

K Nishikura et al. Mol Cell Biol. 1987 Feb.

Abstract

Mouse 3T3 cells were transformed with an antisense c-fos gene fused to a mouse mammary tumor virus promoter. In transformants that integrated a large number of antisense c-fos sequences, the usual large increase in c-fos mRNA and protein following stimulation of quiescent cells by platelet-derived growth factor was blocked in the presence of dexamethasone. These cells subsequently also failed to show the stimulation of DNA synthesis normally induced by platelet-derived growth factor. Appropriate expression of c-fos appears to be a prerequisite for reentry of quiescent cells into the cell cycle.

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