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. 1987 Feb;84(4):959-62.
doi: 10.1073/pnas.84.4.959.

Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chemical synthesis

C H Li, K Ramasharma, D Yamashiro, D Chung

Gonadotropin-releasing peptide from human follicular fluid: isolation, characterization, and chemical synthesis

C H Li et al. Proc Natl Acad Sci U S A. 1987 Feb.

Abstract

A gonadotropin-releasing peptide has been isolated from human follicular fluid. Its amino acid composition and sequence are completely different from the hypothalamic lutropin-releasing hormone. It is designated human follicular gonadotropin-releasing peptide and abbreviated as hF-GRP. The primary structure of this peptide (H-Thr-Asp-Thr-Ser-His-His-Asp-Gln-Asp-His-Pro-Thr-Phe-Asn-OH) has been confirmed by chemical synthesis. In the mouse pituitary incubation assay, the ED50 value for follitropin or lutropin release is estimated to be 1.2-1.6 nM.

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