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. 2022 Sep;477(9):2249-2255.
doi: 10.1007/s11010-022-04440-1. Epub 2022 Apr 26.

The relationship of double-stranded DNA breaks in blood lymphocytes and obesity without carbohydrate metabolism disorder

Khatimya Kudabayeva  1 , Yerlan Bazargaliyev  2 , Raikul Kosmuratova  2
Affiliations

The relationship of double-stranded DNA breaks in blood lymphocytes and obesity without carbohydrate metabolism disorder

Khatimya Kudabayeva et al. Mol Cell Biochem. 2022 Sep.

Retraction in

Abstract

The purpose of this study was to investigate the effect of body mass index on DNA damage of lymphocytes in obese patients without carbohydrate metabolism disorder in the Kazakh population. Research design is based on a single-stage descriptive study. The sample included 239 patients aged 18-60 years. Among the participants, people with chronic decompensated diseases, with bad habits (smokers, drug users, drinkers) were excluded. Special attention was paid to the exclusion of diabetes mellitus to exclude the effect of hyperglycemia on DNA damage when forming the sample according to WHO criteria. The following were estimated: the diameter of the breaks (Foci dia, µm), the average number of γ-H2AX (n) foci detected per cell. The study of DNA damage of blood lymphocytes in individuals of the Kazakh population showed high rates of DSB with a BMI over 40 kg/m2. The number of breaks per cell in women is significantly higher than in men (p = 0.004). The median test revealed a significant difference in the number of DSBs between different age groups (χ2 = 10.39, p = 0.0155). Obesity is now gaining momentum, so the study of the effect of body mass index on lymphocyte DNA damage in obese patients without impaired carbohydrate metabolism gives valuable results in the treatment of this disease.

Keywords: Blood lymphocytes; DNA damage; Gender; Obesity; γ-H2AX.

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References

    1. Ortega FB, Lavie CJ, Blair SN (2016) Obesity and cardiovascular disease. Circ Res 118(11):1752–1770. https://doi.org/10.1161/circresaha.115.306883 - DOI - PubMed
    1. Merder-Coşkun D, Uzuner A, Keniş-Coşkun Ö, Çelenlioğlu AE, Akman M, Karadağ-Saygı E (2017) Relationship between obesity and musculoskeletal system findings among children and adolescents. Turk J Phys Med Rehab 63(3):207–214. https://doi.org/10.5606/tftrd.2017.422 - DOI
    1. Lennon H, Sperrin M, Badrick E, Renehan AG (2016) The obesity paradox in cancer. Curr Oncol Rep 18(9):56. https://doi.org/10.1007/s11912-016-0539-4 - DOI - PubMed - PMC
    1. Apovian CM (2016) Obesity: definition, comorbidities, causes, and burden. Am J Manag Care 22:176–185
    1. Li G, Zhang H, Cao K, Zhai Zh, Wang Zh, Yang L, Han J (2022) Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity. Mol Cell Biochem. https://doi.org/10.1007/s11010-022-04362-y - DOI - PubMed - PMC

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