Published Erratum
doi: 10.1038/s41588-022-01079-y.
Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Julien Barc #
1
2
, Rafik Tadros #
3
4
, Charlotte Glinge #
3
5
, David Y Chiang #
6
, Mariam Jouni #
7
, Floriane Simonet #
8
, Sean J Jurgens
9
, Manon Baudic
8
, Michele Nicastro
3
, Franck Potet
7
, Joost A Offerhaus
3
, Roddy Walsh
3
, Seung Hoan Choi
9
, Arie O Verkerk
3
10
, Yuka Mizusawa
11
3
, Soraya Anys
8
, Damien Minois
8
, Marine Arnaud
8
, Josselin Duchateau
12
13
14
15
, Yanushi D Wijeyeratne
11
16
17
, Alison Muir
18
, Michael Papadakis
16
17
, Silvia Castelletti
19
, Margherita Torchio
20
, Cristina Gil Ortuño
21
, Javier Lacunza
22
, Daniela F Giachino
23
24
, Natascia Cerrato
25
, Raphaël P Martins
26
, Oscar Campuzano
27
28
29
30
, Sonia Van Dooren
11
31
, Aurélie Thollet
8
, Florence Kyndt
8
, Andrea Mazzanti
11
32
, Nicolas Clémenty
33
, Arnaud Bisson
33
, Anniek Corveleyn
34
, Birgit Stallmeyer
35
, Sven Dittmann
35
, Johan Saenen
36
, Antoine Noël
37
, Shohreh Honarbakhsh
38
, Boris Rudic
39
40
, Halim Marzak
41
, Matthew K Rowe
42
, Claire Federspiel
43
, Sophie Le Page
44
, Leslie Placide
45
, Antoine Milhem
46
, Hector Barajas-Martinez
47
, Britt-Maria Beckmann
48
49
, Ingrid P Krapels
50
, Johannes Steinfurt
51
, Bo Gregers Winkel
11
5
, Reza Jabbari
11
5
, Moore B Shoemaker
52
, Bas J Boukens
10
, Doris Škorić-Milosavljević
3
, Hennie Bikker
11
53
, Federico Manevy
3
, Peter Lichtner
54
, Marta Ribasés
55
, Thomas Meitinger
54
, Martina Müller-Nurasyid
56
57
58
59
; KORA-Study Group; Jan H Veldink
60
, Leonard H van den Berg
60
, Philip Van Damme
61
, Daniele Cusi
62
, Chiara Lanzani
63
, Sidwell Rigade
8
, Eric Charpentier
8
64
, Estelle Baron
8
, Stéphanie Bonnaud
8
64
, Simon Lecointe
8
, Audrey Donnart
8
64
, Hervé Le Marec
8
, Stéphanie Chatel
8
, Matilde Karakachoff
8
, Stéphane Bézieau
8
, Barry London
65
, Jacob Tfelt-Hansen
11
5
66
, Dan Roden
67
68
69
, Katja E Odening
51
70
, Marina Cerrone
71
, Larry A Chinitz
71
, Paul G Volders
72
, Maarten P van de Berg
73
, Gabriel Laurent
74
, Laurence Faivre
75
, Charles Antzelevitch
47
, Stefan Kääb
11
48
76
, Alain Al Arnaout
46
, Jean-Marc Dupuis
44
, Jean-Luc Pasquie
77
, Olivier Billon
43
, Jason D Roberts
42
, Laurence Jesel
41
78
, Martin Borggrefe
39
40
, Pier D Lambiase
38
79
, Jacques Mansourati
37
, Bart Loeys
80
, Antoine Leenhardt
11
81
, Pascale Guicheney
82
83
, Philippe Maury
84
, Eric Schulze-Bahr
11
35
, Tomas Robyns
11
85
86
, Jeroen Breckpot
11
34
, Dominique Babuty
33
, Silvia G Priori
11
32
, Carlo Napolitano
11
32
; Nantes Referral Center for inherited cardiac arrhythmia; Carlo de Asmundis
11
29
87
88
, Pedro Brugada
89
, Ramon Brugada
90
, Elena Arbelo
91
, Josep Brugada
92
, Philippe Mabo
26
, Nathalie Behar
26
, Carla Giustetto
25
, Maria Sabater Molina
21
, Juan R Gimeno
11
22
, Can Hasdemir
93
, Peter J Schwartz
11
19
20
, Lia Crotti
11
19
20
94
95
, Pascal P McKeown
18
, Sanjay Sharma
16
17
, Elijah R Behr
11
16
17
, Michel Haissaguerre
12
13
14
15
, Frédéric Sacher
12
13
14
15
, Caroline Rooryck
96
97
, Hanno L Tan
3
98
, Carol A Remme
3
, Pieter G Postema
11
3
, Mario Delmar
99
, Patrick T Ellinor
100
, Steven A Lubitz
100
, Jean-Baptiste Gourraud
8
11
, Michael W Tanck
101
, Alfred L George Jr
7
102
, Calum A MacRae
103
, Paul W Burridge
7
102
, Christian Dina
8
, Vincent Probst #
8
11
, Arthur A Wilde #
11
3
, Jean-Jacques Schott #
8
11
, Richard Redon #
8
11
, Connie R Bezzina #
104
105
Collaborators,
Affiliations
Collaborators
Affiliations
- 1 Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France. julien.barc@univ-nantes.fr.
- 2 European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart, . julien.barc@univ-nantes.fr.
- 3 Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
- 4 Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
- 5 The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
- 6 Medicine, Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 7 Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 8 Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
- 9 The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 10 Department of Medical Biology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
- 11 European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
- 12 IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
- 13 Université Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
- 14 INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
- 15 Electrophysiology and Ablation Unit, Bordeaux University Hospital (CHU), Pessac, France.
- 16 Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
- 17 Cardiology Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust, London, UK.
- 18 Cardiology, Belfast Health and Social Care Trust and Queen's University Belfast, Belfast, UK.
- 19 Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano IRCCS, Milan, Italy.
- 20 Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Italy.
- 21 Cardiogenetic, Unidad de Cardiopatías Familiares, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Murcia, Spain.
- 22 Cardiology, Unidad de Cardiopatías Familiares, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain.
- 23 Clinical and Biological Sciences, Medical Genetics, University of Torino, Orbassano, Italy.
- 24 Medical Genetics, San Luigi Gonzaga University Hospital, Orbassano, Italy.
- 25 Medical Sciences, Cardiology, University of Torino, Torino, Italy.
- 26 Cardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.
- 27 Cardiovascular Genetics Center, University of Girona-IDIBGI, Girona, Spain.
- 28 Medical Science Department, University of Girona, Girona, Spain.
- 29 Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
- 30 Biochemistry and Molecular Genetics Department, Hospital Clinic, University of Barcelona-IDIBAPS, Barcelona, Spain.
- 31 Centre for Medical Genetics, research group Reproduction and Genetics, research cluster Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.
- 32 Molecular Cardiology, ICS Maugeri, IRCCS and Department of Molecular Medicine, University of Pavia, Pavia, Italy.
- 33 Department of Cardiology, CHU Tours, Tours, France.
- 34 Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.
- 35 University Hospital Münster, Institute for Genetics of Heart Diseases (IfGH), Münster, Germany.
- 36 Cardiology, Electrophysiology - Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.
- 37 Department of Cardiology, University Hospital of Brest, Brest, France.
- 38 Cardiology, Medicine, Barts Heart Centre, London, UK.
- 39 Department 1st of Medicine, Cardiology, University Medical Center Mannheim, Mannheim, Germany.
- 40 German Center for Cardiovascular Research (DZHK), Mannheim, Germany.
- 41 Department of Cardiology, University Hospital of Strasbourg, Strasbourg, France.
- 42 Medicine, Cardiology, Western University, London, Ontario, Canada.
- 43 Department of Cardiovascular Medicine, Vendée Hospital, Service de Cardiologie, La Roche sur Yon, France.
- 44 Service de cardiologie, CHU Angers, Angers, France.
- 45 Department of Cardiology, CHU Montpellier, Montpellier, France.
- 46 Department of Cardiology, CH La Rochelle, La Rochelle, France.
- 47 Lankenau Institute for Medical Research, Wynnewood, PA, USA.
- 48 Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
- 49 University Hospital of the Johann Wolfgang Goethe University Frankfurt, Institute of Legal Medicine, Frankfurt, Germany.
- 50 Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
- 51 Department of Cardiology and Angiology I, Heart Center, University Freiburg, Freiburg, Germany.
- 52 Medicine, Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 53 Genome Diagnostics Laboratory, Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands.
- 54 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
- 55 Psychiatric Genetics Unit, Institute Vall d'Hebron Research (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
- 56 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
- 57 IBE, LMU Munich, Munich, Germany.
- 58 Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
- 59 Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
- 60 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
- 61 Neurology Department University Hospital Leuven, Neuroscience Department KU Leuven, Center for Brain & Disease Research VIB, Leuven, Belgium.
- 62 Scientific Unit, Bio4Dreams - Business Nursery for Life Sciences, Milan, Italy.
- 63 Nephrology, Genomics of Renal Diseases and Hypertension Unit, Università Vita Salute San Raffaele, Milan, Italy.
- 64 Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.
- 65 Department of Internal Medicine, Division of Cardiovascular Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
- 66 Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.
- 67 Medicine, Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 68 Medicine, Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 69 Medicine, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 70 Department of Cardiology, Translational Cardiology, University Hospital Bern, Bern, Switzerland.
- 71 Medicine, Leon H. Charney Division of Cardiology, Heart Rhythm Center and Cardiovascular Genetics Program, New York University School of Medicine, New York, NY, USA.
- 72 Department of Cardiology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands.
- 73 Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
- 74 Cardiology Department, ImVia lab team IFTIM, University Hospital Dijon, Dijon, France.
- 75 Centre de Génétique, FHU TRANSLAD, Dijon, France.
- 76 German Center for Cardiovascular Research (DZHK), Partnersite Munich, Munich, Germany.
- 77 Department of Cardiology, CNRS UMR9214 - Inserm U1046 - PHYMEDEXP, Université de Montpellier et CHU Montpellier, Montpellier, France.
- 78 INSERM 1260 - Regenerative Nanomedecine, University of Strasbourg, Strasbourg, France.
- 79 Institute of Cardiovasculr Science, UCL, Population Health, UCL, London, UK.
- 80 Center for Medical Genetics, Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.
- 81 Department of Cardiology, Hopital Bichat, Paris, France.
- 82 Sorbonne Université, Paris, France.
- 83 UMR_S1166, Faculté de médecine, Sorbonne Université, INSERM, Paris, France.
- 84 Service de cardiologie, Hôpital Rangueil, CHU de Toulouse, Toulouse, France.
- 85 Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
- 86 Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
- 87 Heart Rhythm Management Center, Postgraduate Program in Cardiac Electrophysiology and Pacing Universitair Ziekenhuis, Brussel-Vrije Universiteit Brussel, ERN Heart Guard Center, Brussels, Belgium.
- 88 IDIBAPS, Institut d'Investigació August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
- 89 Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium.
- 90 Hospital Trueta, CiberCV, University of Girona, IDIBGI, Girona, Spain, Barcelona, Spain.
- 91 Arrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
- 92 Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
- 93 Department of Cardiology, Ege University School of Medicine, Bornova, Turkey.
- 94 Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano IRCCS, Milan, Italy.
- 95 Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
- 96 CHU Bordeaux, Service de Génétique Médicale, Bordeaux, France.
- 97 Université de Bordeaux, Maladies Rares: Génétique et Métabolisme (MRGM), INSERM U1211, Bordeaux, France.
- 98 Netherlands Heart Institute, Utrecht, The Netherlands.
- 99 Medicine, Cardiology, New York University School of Medicine, New York, NY, USA.
- 100 Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital and Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Boston, MA, USA.
- 101 Clinical Epidemiology, Biostatistics and Bioinformatics, Clinical Methods and Public Health, Amsterdam Public Health, Amsterdam, The Netherlands.
- 102 Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 103 Medicine, Cardiovascular Medicine, Genetics and Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
- 104 European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart, . c.r.bezzina@amsterdamumc.nl.
- 105 Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. c.r.bezzina@amsterdamumc.nl.
# Contributed equally.
- PMID: 35474365
- DOI: 10.1038/s41588-022-01079-y
Item in Clipboard
Published Erratum
Author Correction: Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Julien Barc et al.
Nat Genet.
2022 May.
Display options
Format
doi: 10.1038/s41588-022-01079-y.
Authors
Julien Barc #
1
2
, Rafik Tadros #
3
4
, Charlotte Glinge #
3
5
, David Y Chiang #
6
, Mariam Jouni #
7
, Floriane Simonet #
8
, Sean J Jurgens
9
, Manon Baudic
8
, Michele Nicastro
3
, Franck Potet
7
, Joost A Offerhaus
3
, Roddy Walsh
3
, Seung Hoan Choi
9
, Arie O Verkerk
3
10
, Yuka Mizusawa
11
3
, Soraya Anys
8
, Damien Minois
8
, Marine Arnaud
8
, Josselin Duchateau
12
13
14
15
, Yanushi D Wijeyeratne
11
16
17
, Alison Muir
18
, Michael Papadakis
16
17
, Silvia Castelletti
19
, Margherita Torchio
20
, Cristina Gil Ortuño
21
, Javier Lacunza
22
, Daniela F Giachino
23
24
, Natascia Cerrato
25
, Raphaël P Martins
26
, Oscar Campuzano
27
28
29
30
, Sonia Van Dooren
11
31
, Aurélie Thollet
8
, Florence Kyndt
8
, Andrea Mazzanti
11
32
, Nicolas Clémenty
33
, Arnaud Bisson
33
, Anniek Corveleyn
34
, Birgit Stallmeyer
35
, Sven Dittmann
35
, Johan Saenen
36
, Antoine Noël
37
, Shohreh Honarbakhsh
38
, Boris Rudic
39
40
, Halim Marzak
41
, Matthew K Rowe
42
, Claire Federspiel
43
, Sophie Le Page
44
, Leslie Placide
45
, Antoine Milhem
46
, Hector Barajas-Martinez
47
, Britt-Maria Beckmann
48
49
, Ingrid P Krapels
50
, Johannes Steinfurt
51
, Bo Gregers Winkel
11
5
, Reza Jabbari
11
5
, Moore B Shoemaker
52
, Bas J Boukens
10
, Doris Škorić-Milosavljević
3
, Hennie Bikker
11
53
, Federico Manevy
3
, Peter Lichtner
54
, Marta Ribasés
55
, Thomas Meitinger
54
, Martina Müller-Nurasyid
56
57
58
59
; KORA-Study Group; Jan H Veldink
60
, Leonard H van den Berg
60
, Philip Van Damme
61
, Daniele Cusi
62
, Chiara Lanzani
63
, Sidwell Rigade
8
, Eric Charpentier
8
64
, Estelle Baron
8
, Stéphanie Bonnaud
8
64
, Simon Lecointe
8
, Audrey Donnart
8
64
, Hervé Le Marec
8
, Stéphanie Chatel
8
, Matilde Karakachoff
8
, Stéphane Bézieau
8
, Barry London
65
, Jacob Tfelt-Hansen
11
5
66
, Dan Roden
67
68
69
, Katja E Odening
51
70
, Marina Cerrone
71
, Larry A Chinitz
71
, Paul G Volders
72
, Maarten P van de Berg
73
, Gabriel Laurent
74
, Laurence Faivre
75
, Charles Antzelevitch
47
, Stefan Kääb
11
48
76
, Alain Al Arnaout
46
, Jean-Marc Dupuis
44
, Jean-Luc Pasquie
77
, Olivier Billon
43
, Jason D Roberts
42
, Laurence Jesel
41
78
, Martin Borggrefe
39
40
, Pier D Lambiase
38
79
, Jacques Mansourati
37
, Bart Loeys
80
, Antoine Leenhardt
11
81
, Pascale Guicheney
82
83
, Philippe Maury
84
, Eric Schulze-Bahr
11
35
, Tomas Robyns
11
85
86
, Jeroen Breckpot
11
34
, Dominique Babuty
33
, Silvia G Priori
11
32
, Carlo Napolitano
11
32
; Nantes Referral Center for inherited cardiac arrhythmia; Carlo de Asmundis
11
29
87
88
, Pedro Brugada
89
, Ramon Brugada
90
, Elena Arbelo
91
, Josep Brugada
92
, Philippe Mabo
26
, Nathalie Behar
26
, Carla Giustetto
25
, Maria Sabater Molina
21
, Juan R Gimeno
11
22
, Can Hasdemir
93
, Peter J Schwartz
11
19
20
, Lia Crotti
11
19
20
94
95
, Pascal P McKeown
18
, Sanjay Sharma
16
17
, Elijah R Behr
11
16
17
, Michel Haissaguerre
12
13
14
15
, Frédéric Sacher
12
13
14
15
, Caroline Rooryck
96
97
, Hanno L Tan
3
98
, Carol A Remme
3
, Pieter G Postema
11
3
, Mario Delmar
99
, Patrick T Ellinor
100
, Steven A Lubitz
100
, Jean-Baptiste Gourraud
8
11
, Michael W Tanck
101
, Alfred L George Jr
7
102
, Calum A MacRae
103
, Paul W Burridge
7
102
, Christian Dina
8
, Vincent Probst #
8
11
, Arthur A Wilde #
11
3
, Jean-Jacques Schott #
8
11
, Richard Redon #
8
11
, Connie R Bezzina #
104
105
Collaborators
Affiliations
- 1 Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France. julien.barc@univ-nantes.fr.
- 2 European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart, . julien.barc@univ-nantes.fr.
- 3 Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
- 4 Department of Medicine, Cardiovascular Genetics Center, Montreal Heart Institute and Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
- 5 The Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
- 6 Medicine, Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
- 7 Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 8 Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, France.
- 9 The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
- 10 Department of Medical Biology, University of Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
- 11 European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart.
- 12 IHU Liryc, Electrophysiology and Heart Modeling Institute, fondation Bordeaux Université, Pessac-Bordeaux, France.
- 13 Université Bordeaux, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
- 14 INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France.
- 15 Electrophysiology and Ablation Unit, Bordeaux University Hospital (CHU), Pessac, France.
- 16 Molecular and Clinical Sciences Research Institute, St. George's, University of London, London, UK.
- 17 Cardiology Clinical Academic Group, St. George's University Hospitals' NHS Foundation Trust, London, UK.
- 18 Cardiology, Belfast Health and Social Care Trust and Queen's University Belfast, Belfast, UK.
- 19 Center for Cardiac Arrhythmias of Genetic Origin, Istituto Auxologico Italiano IRCCS, Milan, Italy.
- 20 Laboratory of Cardiovascular Genetics, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Italy.
- 21 Cardiogenetic, Unidad de Cardiopatías Familiares, Instituto Murciano de Investigación Biosanitaria, Universidad de Murcia, Murcia, Spain.
- 22 Cardiology, Unidad de Cardiopatías Familiares, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Murcia, Spain.
- 23 Clinical and Biological Sciences, Medical Genetics, University of Torino, Orbassano, Italy.
- 24 Medical Genetics, San Luigi Gonzaga University Hospital, Orbassano, Italy.
- 25 Medical Sciences, Cardiology, University of Torino, Torino, Italy.
- 26 Cardiologie et Maladies vasculaires, Université Rennes1 - CHU Rennes, Rennes, France.
- 27 Cardiovascular Genetics Center, University of Girona-IDIBGI, Girona, Spain.
- 28 Medical Science Department, University of Girona, Girona, Spain.
- 29 Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
- 30 Biochemistry and Molecular Genetics Department, Hospital Clinic, University of Barcelona-IDIBAPS, Barcelona, Spain.
- 31 Centre for Medical Genetics, research group Reproduction and Genetics, research cluster Reproduction, Genetics and Regenerative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.
- 32 Molecular Cardiology, ICS Maugeri, IRCCS and Department of Molecular Medicine, University of Pavia, Pavia, Italy.
- 33 Department of Cardiology, CHU Tours, Tours, France.
- 34 Department of Human Genetics, Catholic University Leuven, Leuven, Belgium.
- 35 University Hospital Münster, Institute for Genetics of Heart Diseases (IfGH), Münster, Germany.
- 36 Cardiology, Electrophysiology - Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.
- 37 Department of Cardiology, University Hospital of Brest, Brest, France.
- 38 Cardiology, Medicine, Barts Heart Centre, London, UK.
- 39 Department 1st of Medicine, Cardiology, University Medical Center Mannheim, Mannheim, Germany.
- 40 German Center for Cardiovascular Research (DZHK), Mannheim, Germany.
- 41 Department of Cardiology, University Hospital of Strasbourg, Strasbourg, France.
- 42 Medicine, Cardiology, Western University, London, Ontario, Canada.
- 43 Department of Cardiovascular Medicine, Vendée Hospital, Service de Cardiologie, La Roche sur Yon, France.
- 44 Service de cardiologie, CHU Angers, Angers, France.
- 45 Department of Cardiology, CHU Montpellier, Montpellier, France.
- 46 Department of Cardiology, CH La Rochelle, La Rochelle, France.
- 47 Lankenau Institute for Medical Research, Wynnewood, PA, USA.
- 48 Department of Medicine I, University Hospital, LMU Munich, Munich, Germany.
- 49 University Hospital of the Johann Wolfgang Goethe University Frankfurt, Institute of Legal Medicine, Frankfurt, Germany.
- 50 Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
- 51 Department of Cardiology and Angiology I, Heart Center, University Freiburg, Freiburg, Germany.
- 52 Medicine, Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 53 Genome Diagnostics Laboratory, Clinical Genetics, Amsterdam UMC, Amsterdam, The Netherlands.
- 54 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
- 55 Psychiatric Genetics Unit, Institute Vall d'Hebron Research (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
- 56 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
- 57 IBE, LMU Munich, Munich, Germany.
- 58 Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
- 59 Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
- 60 Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
- 61 Neurology Department University Hospital Leuven, Neuroscience Department KU Leuven, Center for Brain & Disease Research VIB, Leuven, Belgium.
- 62 Scientific Unit, Bio4Dreams - Business Nursery for Life Sciences, Milan, Italy.
- 63 Nephrology, Genomics of Renal Diseases and Hypertension Unit, Università Vita Salute San Raffaele, Milan, Italy.
- 64 Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, Nantes, France.
- 65 Department of Internal Medicine, Division of Cardiovascular Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
- 66 Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark.
- 67 Medicine, Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 68 Medicine, Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
- 69 Medicine, Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
- 70 Department of Cardiology, Translational Cardiology, University Hospital Bern, Bern, Switzerland.
- 71 Medicine, Leon H. Charney Division of Cardiology, Heart Rhythm Center and Cardiovascular Genetics Program, New York University School of Medicine, New York, NY, USA.
- 72 Department of Cardiology, CARIM, Maastricht University Medical Center, Maastricht, The Netherlands.
- 73 Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
- 74 Cardiology Department, ImVia lab team IFTIM, University Hospital Dijon, Dijon, France.
- 75 Centre de Génétique, FHU TRANSLAD, Dijon, France.
- 76 German Center for Cardiovascular Research (DZHK), Partnersite Munich, Munich, Germany.
- 77 Department of Cardiology, CNRS UMR9214 - Inserm U1046 - PHYMEDEXP, Université de Montpellier et CHU Montpellier, Montpellier, France.
- 78 INSERM 1260 - Regenerative Nanomedecine, University of Strasbourg, Strasbourg, France.
- 79 Institute of Cardiovasculr Science, UCL, Population Health, UCL, London, UK.
- 80 Center for Medical Genetics, Cardiogenetics, University of Antwerp/Antwerp University Hospital, Edegem, Belgium.
- 81 Department of Cardiology, Hopital Bichat, Paris, France.
- 82 Sorbonne Université, Paris, France.
- 83 UMR_S1166, Faculté de médecine, Sorbonne Université, INSERM, Paris, France.
- 84 Service de cardiologie, Hôpital Rangueil, CHU de Toulouse, Toulouse, France.
- 85 Cardiovascular Diseases, University Hospitals Leuven, Leuven, Belgium.
- 86 Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
- 87 Heart Rhythm Management Center, Postgraduate Program in Cardiac Electrophysiology and Pacing Universitair Ziekenhuis, Brussel-Vrije Universiteit Brussel, ERN Heart Guard Center, Brussels, Belgium.
- 88 IDIBAPS, Institut d'Investigació August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
- 89 Heart Rhythm Management Center, UZ Brussel-VUB, Brussels, Belgium.
- 90 Hospital Trueta, CiberCV, University of Girona, IDIBGI, Girona, Spain, Barcelona, Spain.
- 91 Arrhythmia Section, Cardiology Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
- 92 Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
- 93 Department of Cardiology, Ege University School of Medicine, Bornova, Turkey.
- 94 Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital, Istituto Auxologico Italiano IRCCS, Milan, Italy.
- 95 Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
- 96 CHU Bordeaux, Service de Génétique Médicale, Bordeaux, France.
- 97 Université de Bordeaux, Maladies Rares: Génétique et Métabolisme (MRGM), INSERM U1211, Bordeaux, France.
- 98 Netherlands Heart Institute, Utrecht, The Netherlands.
- 99 Medicine, Cardiology, New York University School of Medicine, New York, NY, USA.
- 100 Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital and Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Boston, MA, USA.
- 101 Clinical Epidemiology, Biostatistics and Bioinformatics, Clinical Methods and Public Health, Amsterdam Public Health, Amsterdam, The Netherlands.
- 102 Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 103 Medicine, Cardiovascular Medicine, Genetics and Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
- 104 European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart: ERN GUARD-Heart, . c.r.bezzina@amsterdamumc.nl.
- 105 Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. c.r.bezzina@amsterdamumc.nl.
# Contributed equally.
- PMID: 35474365
- DOI: 10.1038/s41588-022-01079-y
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Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.Barc J, Tadros R, Glinge C, Chiang DY, Jouni M, Simonet F, Jurgens SJ, Baudic M, Nicastro M, Potet F, Offerhaus JA, Walsh R, Choi SH, Verkerk AO, Mizusawa Y, Anys S, Minois D, Arnaud M, Duchateau J, Wijeyeratne YD, Muir A, Papadakis M, Castelletti S, Torchio M, Ortuño CG, Lacunza J, Giachino DF, Cerrato N, Martins RP, Campuzano O, Van Dooren S, Thollet A, Kyndt F, Mazzanti A, Clémenty N, Bisson A, Corveleyn A, Stallmeyer B, Dittmann S, Saenen J, Noël A, Honarbakhsh S, Rudic B, Marzak H, Rowe MK, Federspiel C, Le Page S, Placide L, Milhem A, Barajas-Martinez H, Beckmann BM, Krapels IP, Steinfurt J, Winkel BG, Jabbari R, Shoemaker MB, Boukens BJ, Škorić-Milosavljević D, Bikker H, Manevy F, Lichtner P, Ribasés M, Meitinger T, Müller-Nurasyid M; KORA-Study Group; Veldink JH, van den Berg LH, Van Damme P, Cusi D, Lanzani C, Rigade S, Charpentier E, Baron E, Bonnaud S, Lecointe S, Donnart A, Le Marec H, Chatel S, Karakachoff M, Bézieau S, London B, Tfelt-Hansen J, Roden D, Odening KE, Cerrone M, Chinitz LA, Volders PG, van de Berg MP, Laurent G, Faivre L, Antzelevitch C, Kääb S, Arnaout AA, Dupuis JM, Pasquie JL, Billon O, Roberts JD, Jesel L, Borggrefe M, Lambiase PD, Mansourati J, Loe… See abstract for full author list ➔ Barc J, et al. Nat Genet. 2022 Mar;54(3):232-239. doi: 10.1038/s41588-021-01007-6. Epub 2022 Feb 24. Nat Genet. 2022. PMID: 35210625 Free PMC article.
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