Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Feb 11;3(3):100549.
doi: 10.1016/j.xcrm.2022.100549. eCollection 2022 Mar 15.

Antiviral agents for the treatment of COVID-19: Progress and challenges

Manmeet Singh  1 , Emmie de Wit  1
Affiliations

Antiviral agents for the treatment of COVID-19: Progress and challenges

Manmeet Singh et al. Cell Rep Med. .

Abstract

The COVID-19 pandemic has seen clinical development and use of antiviral therapies at an unprecedented speed. Antiviral therapies have greatly improved the clinical outcome in COVID-19 patients, especially when administered early after diagnosis. Here, we discuss the successes and challenges of COVID-19 antiviral therapies and lessons for future pandemics.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Overview of antiviral therapies currently available for the treatment of COVID-19 COVID-19 disease stages are indicated with percentage of patients that fall into each category. Antiviral therapies prescribed during these disease stages are indicated. Antiviral therapies recommended in the NIH COVID-19 treatment guidelines are shown in bold; italicized therapies are currently under consideration by the FDA, or FDA EUA application is pending after positive results in clinical trials. NSAIDs, non-steroidal anti-inflammatory drugs.
See this image and copyright information in PMC

References

    1. Ryu W.S. Molecular Virology of Human Pathogenic Viruses. Elsevier; 2017. Antiviral Therapy; pp. 367–381. - DOI
    1. National Institutes of Health Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. 2021. https://www.covid19treatmentguidelines.nih.gov/ - PubMed
    1. Griffin D.O., Brennan-Rieder D., Ngo B., Kory P., Confalonieri M., Shapiro L., Iglesias J., Dube M., Nanda N., In G.K., et al. The Importance of Understanding the Stages of COVID-19 in Treatment and Trials. AIDS Rev. 2021;23:40–47. doi: 10.24875/AIDSRev.200001261. - DOI - PubMed
    1. Tran A., Witek T.J., Jr. The Emergency Use Authorization of Pharmaceuticals: History and Utility During the COVID-19 Pandemic. Pharmaceut. Med. 2021;35:203–213. doi: 10.1007/s40290-021-00397-6. - DOI - PMC - PubMed
    1. Regulatory Affairs Professionals Society COVID-19 therapeutics tracker. 2021. https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-the...

Substances