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Case Reports
. 2021;28(2):349-354.
doi: 10.15388/Amed.2021.28.2.12. Epub 2021 Aug 26.

Case of Severe Treatment-Resistant Cryptogenic Organizing Pneumonia

Domas Grigoravičius  1 , Edvardas Žurauskas  2 , Vygantas Gruslys  3 , Rolandas Zablockis  3 , Edvardas Danila  3
Affiliations
Case Reports

Case of Severe Treatment-Resistant Cryptogenic Organizing Pneumonia

Domas Grigoravičius et al. Acta Med Litu. 2021.

Abstract
in English, Lithuanian

Cryptogenic organizing pneumonia is a rare interstitial lung disease with different onset of symptoms, which responds rapidly to glucocorticoid treatment. We present a case of cryptogenic organizing pneumonia which manifested as a progressive 3-year dyspnea that ultimately has led to acute respiratory failure. Moreover, treatment with prednisone for this patient exhibited slow onset of the effect.

Santrauka. Kriptogeninė organizuojanti pneumonija yra reta intersticinė plaučių liga, pasireiškianti įvairiais simptomais, kurie dažniausiai gretai išnyksta gydant gliukokortikoidais. Pristatome kriptogeninės organizuojančios pneumonijos atvejį, pasireiškusį 3 metus progresuojančiu dusuliu ir galiausiai išsivysčiusiu kvėpavimo nepakankamumu. Gydymas prednizolonu šiuo atveju nesukėlė tikėtino greito klinikinio atsako.Raktiniai žodžiai: organizuojanti pneumonija; ūmus kvėpavimo nepakankamumas; gydymas prednizolonu.

Keywords: acute respiratory failure; organizing pneumonia; prednisone therapy.

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Figures

Figure 1.
Figure 1.
Chest CT (2019.12.06) showing multiple bilateral confluent irregular opacities mainly in the lower lobes, ground-glass appearance, and traction bronchiectasis.
Figure 2.
Figure 2.
Control chest roentgenogram (2020.02.12) showing bilateral interstitium infiltration (white asterisks) predominantly in the lower segments and focal infiltrative opacities.
Figure 3.
Figure 3.
HEx10.Lung biopsy showing mesenchymal proliferates in the alveoli (black stars), thickened alveolar septum with lymphocytes infiltration (black arrows) and edema in the alveolus (blue star).
Figure 4.
Figure 4.
Chest roentgenogram (2020.05.06) after three months of prednisone treatment. Signs of interstitium infiltration (white asterisks) are decreased (improvement more pronounced on the left side) than in the control chest roentgenogram.
See this image and copyright information in PMC

References

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