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Case Reports
. 2022 Apr 20;10(4):e05769.
doi: 10.1002/ccr3.5769. eCollection 2022 Apr.

Concomitant lymphoplasmacytic lymphoma, multiple myeloma, and amyloidosis: A diagnostic and therapeutic challenge

Candela Ceballos  1   2 , Cristina Alburquerque  1   2 , Amaya Zabalza  1   2 , Iván Quispe  1   2 , Ángel Panizo  2   3 , Yolanda Burguete  1   2 , Ana Margarita Redondo  1   2 , María Carmen Mateos  1   2
Affiliations
Case Reports

Concomitant lymphoplasmacytic lymphoma, multiple myeloma, and amyloidosis: A diagnostic and therapeutic challenge

Candela Ceballos et al. Clin Case Rep. .

Abstract

We report a case based on simultaneous occurrence of Waldenström macroglobulinemia, myeloma and amyloidosis as a collision neoplasm. The strangeness and severity of the case presented a diagnostic and therapeutic challenge, which required individualised treatment and close follow-up to achieved stringent complete response.

Keywords: Waldenström macroglobulinemia; amyloidosis; autologous stem cell transplant; myeloma.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
(A) Tumor is densely cellular and shows diffuse growth; with three cell types are seen in the tumor: small lymphocytes, plasma cells, and plasmacytoid cells (Hematoxylin and eosin [H&E], ×200). (B) Large plasmacytoid cells of large size and anaplasia with frequent binucleation, large nucleoli, and intranuclear pseudoinclusions (H&E, ×400). (C) Small lymphocytes were positive for CD45. (D) Small lymphocytes and some plasmacytoid cells were positive for CD20. (E and F) In situ hybridization shows clonal restriction of Lambda light‐chains. (G) Interstitial deposit between tumor cells of a homogeneous, hyaline acellular material, slightly Periodic acid–Schiff (PAS) positive (PAS, ×400). (H) Plasma cells and plasmacytoid cells of large size and anaplasia were diffusely positive for CD138. (I) The interstitial deposit was Congo red positive (congo red, ×400). (J) Plasma cells showed diffuse and intense nuclear positivity for cyclin D1
See this image and copyright information in PMC

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