More Than Meets the Eye: "In Vivo" Diagnosis of Heidenhain Variant of Sporadic Creutzfeldt-Jakob Disease

Affiliations

¹ Neurology Department (EP, TR, GP), IRCCS INRCA, Ancona, Italy ; Eye Clinic (Paolo Pelliccioni), Polytechnic University of Marche, University Hospital "Ospedali Riuniti," Ancona, Italy ; Radiology Unit (MS, RR), IRCCS INRCA, Ancona, Italy ; IRCCS Istituto delle Scienze Neurologiche di Bologna (Piero Parchi), Bologna, Italy; and Department of Experimental, Diagnostic and Specialty Medicine (DIMES) (Piero Parchi), University of Bologna, Bologna, Italy.

Eleonora Potente et al. J Neuroophthalmol. 2022.

. 2022 Mar 1;42(1):e423-e426.

doi: 10.1097/WNO.0000000000001389. Epub 2021 Aug 18.

¹ Neurology Department (EP, TR, GP), IRCCS INRCA, Ancona, Italy ; Eye Clinic (Paolo Pelliccioni), Polytechnic University of Marche, University Hospital "Ospedali Riuniti," Ancona, Italy ; Radiology Unit (MS, RR), IRCCS INRCA, Ancona, Italy ; IRCCS Istituto delle Scienze Neurologiche di Bologna (Piero Parchi), Bologna, Italy; and Department of Experimental, Diagnostic and Specialty Medicine (DIMES) (Piero Parchi), University of Bologna, Bologna, Italy.

No abstract available

Conflict of interest statement

The authors report no conflicts of interest.

1. Baiardi S, Capellari S, Ladogana A, Strumia S, Santangelo M, Pocchiari M, Parchi P. Revisiting the Heidenhain variant of Creutzfeldt-Jakob disease: evidence for prion type variability influencing clinical course and laboratory findings. J Alzheimers Dis. 2016;50:465–476.
1. Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N. Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med. 2011;17:175–178.
1. Franceschini A, Baiardi S, Hughson AG, McKenzie N, Moda F, Rossi M, Capellari S, Green A, Giaccone G, Caughey B, Parchi P. High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions. Sci Rep. 2017;7:10655.
1. Cooper SA, Murray KL, Heath CA, Will RG, Knight RS. Isolated visual symptoms at onset in sporadic Creutzfeldt-Jakob disease: the clinical phenotype of the ‟Heidenhain variant.” Br J Ophthalmol. 2005;89:1341–1342.
1. Zerr I, Kallenberg K, Summers DM, Romero C, Taratuto A, Heinemann U, Breithaupt M, Varges D, Meissner B, Ladogana A, Schuur M, Haik S, Collins SJ, Jansen GH, Stokin GB, Pimentel J, Hewer E, Collie D, Smith P, Roberts H, Brandel JP, van Duijn C, Pocchiari M, Begue C, Cras P, Will RG, Sanchez-Juan P. Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Brain. 2009;132:2659–2668.