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Observational Study
. 2022 Sep-Oct;51(5):715-725.
doi: 10.1080/15374416.2022.2034634. Epub 2022 Apr 27.

Eighteen-month Course and Outcome of Adolescent Restrictive Eating Disorders: Persistence, Crossover, and Recovery

Lauren Breithaupt  1   2 , Danielle L Kahn  3 , Meghan Slattery  3 , Franziska Plessow  2   3 , Christopher Mancuso  3 , Alyssa Izquierdo  3 , Melissa J Dreier  1 , Kendra Becker  1   2 , Debra L Franko  4 , Jennifer J Thomas  1   2 , Laura Holsen  2   5 , Elizabeth A Lawson  2   3 , Madhusmita Misra  2   3   6 , Kamryn T Eddy  1   2
Affiliations
Observational Study

Eighteen-month Course and Outcome of Adolescent Restrictive Eating Disorders: Persistence, Crossover, and Recovery

Lauren Breithaupt et al. J Clin Child Adolesc Psychol. 2022 Sep-Oct.

Abstract

Objective: In adults, low-weight restrictive eating disorders, including anorexia nervosa (AN), are marked by chronicity and diagnostic crossover from restricting to binge-eating/purging. Less is known about the naturalistic course of these eating disorders in adolescents, particularly atypical AN (atyp-AN) and avoidant/restrictive food intake disorder (ARFID). To inform nosology of low-weight restrictive eating disorders in adolescents, we examined outcomes including persistence, crossover, and recovery in an 18-month observational study.

Method: We assessed 82 women (ages 10-23 years) with low-weight eating disorders including AN (n = 40; 29 restricting, 11 binge-eating/purging), atyp-AN (n = 26; 19 restricting, seven binge-eating/purging), and ARFID (n = 16) at baseline, nine months (9 M; 75% retention), and 18 months (18 M; 73% retention) via semi-structured interviews. First-order Markov modeling was used to determine diagnostic persistence, crossover, and recovery occurring at 9 M or 18 M.

Results: Among all diagnoses, the likelihood of remaining stable within a given diagnosis was greater than that of transitioning, with the greatest probability among ARFID (0.84) and AN-R (0.62). Persistence of BP and atypical presentations at follow-up periods was less stable (AN-BP probability 0.40; atyp-AN-R probability 0.48; atyp-AN-BP probability, 0.50). Crossover from binge-eating/purging to restricting occurred 72% of the time; crossover from restricting to binge-eating/purging occurred 23% of the time. The likelihood of stable recovery (e.g., recovery at both 9 M and 18 M) was between 0.00 and 0.36.

Conclusion: Across groups, intake diagnosis persisted in about two-thirds, and recovery was infrequent, underscoring the urgent need for innovative treatment approaches to these illnesses. Frequent crossover between AN and atyp-AN supports continuity between typical and atypical presentations, whereas no crossover to ARFID supports its distinction.

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Conflict of interest statement

The interests of all authors employed at Massachusetts General Hospital were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict-of-interest policies. Ms. Kahn, Ms. Slattery, Ms. Izquierdo, Ms. Dreier, Dr. Franko, and Mr. Mancuso have no conflicts of interest to report.

Figures

Figure 1.
Figure 1.
Longitudinal course at 9- and 18-month follow-up by intake diagnosis.
See this image and copyright information in PMC

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