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Meta-Analysis
. 2022 Apr 27;17(4):e0267571.
doi: 10.1371/journal.pone.0267571. eCollection 2022.

Prevalence and determinants of late-stage presentation among cervical cancer patients, a systematic review and meta-analysis

Tiwabwork Tekalign  1 , Mister Teshome  1
Affiliations
Meta-Analysis

Prevalence and determinants of late-stage presentation among cervical cancer patients, a systematic review and meta-analysis

Tiwabwork Tekalign et al. PLoS One. .

Abstract

Background: An estimated 570,000 women were diagnosed with cervical cancer worldwide, and about 311,000 women died from the disease. Cervical cancer is possibly the most curable human cancer; if detected at the precancerous stage. Additionally, early diagnosis and management other factors are essential to decrease mortality rate among those patients. So this review was aimed to identify the prevalence and determinants of late-stage presentation among cervical cancer patients.

Methods: A systematic search had carried out on PubMed, EMBASE, MEDLINE, Cochrane, Scopus, Web of Science CINAHL, and manually on Google Scholar. This meta-analysis follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The modified Newcastle-Ottawa Scale (NOS) was used to assess the quality of each study. A meta-analysis was done using a random-effects method using the STATA™ Version 14 software.

Result: Twenty-five studies from 3 world regions with 53,233 participants were enrolled in this meta-analysis. The overall estimated global pooled prevalence of late-stage presentation among cervical cancer patients with a random-effects model was 60.66% (95% CI: 56.27, 65.06). The subgroup analysis revealed that the prevalence of late-stage presentation was 62.60% in Africa, 69.30% in Asia, 46.51% in Europe, and 50.16% in North America. Educational status (p = 0.031) and place of residence (p = 0.004) are determinants of late-stage presentation.

Conclusion: The results of this meta-analysis indicated that the prevalence of late-stage presentation of cervical cancer is substantially high. Place of residence and educational status were significantly associated with late-stage presentation. Health care organizations should work on early screening, management, and on increasing community awareness to minimize late stage at presentation among those patients.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. PRISMA flowchart diagram of the study selection.
Fig 2
Fig 2. Forest plot showing pooled global prevalence of late stage presentation among cervical cancer patient.
Fig 3
Fig 3. Subgroup analysis of global late stage presentation among cervical cancer patients.
Fig 4
Fig 4. Funnel plot to test the publication bias in 25 studies with 95% confidence limits.
Fig 5
Fig 5. Sensitivity analysis of pooled prevalence of late stage presentation for each study being removed one at a time.
See this image and copyright information in PMC

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