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. 2022 Jun 15:367:577868.
doi: 10.1016/j.jneuroim.2022.577868. Epub 2022 Apr 18.

Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis

C Kyllesbech  1 , N Trier  1 , R Slibinskas  2 , E Ciplys  2 , A Tsakiri  1 , J L Frederiksen  1 , G Houen  3
Affiliations

Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis

C Kyllesbech et al. J Neuroimmunol. .

Abstract

Intrathecal antibody synthesis to viruses is associated with multiple sclerosis (MS). Here, IgG levels to Epstein-Barr virus (EBV) BamHI-A rightward frame 1 (BARF1), EBV nuclear antigen 1 (EBNA1), mumps virus (MuV) nucleoprotein (NuP), measles virus (MeV) NuP and rubella virus (RuV) capsid protein (CaP) were found to be elevated in serum and cerebrospinal fluid (CSF) of MS patients compared to healthy controls (HCs), whereas the opposite was found for cytomegalovirus (CMV) pp52. Strong correlations between serum and CSF IgG were seen for MeV, CMV and RuV in both MS patients and HCs. The antigen panel obtained high sensitivity (81%) and specificity (86%), demonstrating that antigen panels may supplement the total IgG index used in MS diagnosis.

Keywords: Antibody index; Antigen; Cerebrospinal fluid; Multiple sclerosis; Oligoclonal bands; Serum; Virus.

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