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Review
. 2022 Apr 27;21(1):72.
doi: 10.1186/s12934-022-01799-0.

Engineered probiotics

Junheng Ma #  1   2 , Yuhong Lyu #  1 , Xin Liu  3 , Xu Jia  2   4 , Fangyun Cui  5 , Xiaoheng Wu  1   2 , Shanshan Deng  6 , Changwu Yue  7
Affiliations
Review

Engineered probiotics

Junheng Ma et al. Microb Cell Fact. .

Erratum in

  • Correction to: Engineered probiotics.
    Ma J, Lyu Y, Liu X, Jia X, Cui F, Wu X, Deng S, Yue C. Ma J, et al. Microb Cell Fact. 2022 May 24;21(1):93. doi: 10.1186/s12934-022-01820-6. Microb Cell Fact. 2022. PMID: 35610719 Free PMC article. No abstract available.

Abstract

Engineered probiotics are a kind of new microorganisms produced by modifying original probiotics through gene editing. With the continuous development of tools and technology progresses, engineering renovation of probiotics are becoming more diverse and more feasible. In the past few years there have been some advances in the development of engineered probiotics that will benefit humankind. This review briefly introduces the theoretical basis of gene editing technology and focuses on some recent engineered probiotics researches, including inflammatory bowel disease, bacterial infection, tumor and metabolic diseases. It is hoped that it can provide help for the further development of genetically modified microorganisms, stimulate the potential of engineered probiotics to treat intractable diseases, and provide new ideas for the diagnosis of some diseases or some industrial production.

Keywords: CRISPR; Disease diagnosis and treatment; Engineered probiotics; Gene editing; Genetic engineering; Synthetic biology.

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Conflict of interest statement

The authors declare that they have no competing interests.

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