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. 2022 May-Jun;36(3):1267-1273.
doi: 10.21873/invivo.12826.

Enchondromas of the Hand: Curettage With Autogenous Bone vs. Bioactive Glass S53P4 for Void Augmentation

Nina Lindfors #  1 , Elias Kukkonen #  1 , Antti Stenroos  2 , Panu H Nordback  1 , Turkka Anttila  1 , Samuli Aspinen  3
Affiliations

Enchondromas of the Hand: Curettage With Autogenous Bone vs. Bioactive Glass S53P4 for Void Augmentation

Nina Lindfors et al. In Vivo. 2022 May-Jun.

Abstract

Background/Aim Enchondroma is the most common primary bone tumour of the hand. When surgery is indicated, curettage with or without void augmentation has been described. However, only few comparative studies exist. The aim of this study was to compare the outcomes of hand enchondromas treated with autologous bone graft (AG) and bioactive glass S53P4 (BAG).

Patients and methods: A retrospective comparative analysis was conducted among patients surgically treated for hand enchondromas at a tertiary referral centre during a 17-year period.

Results: A total of 190 patients (116 AG vs. 74 BAG) with 205 enchondromas were included. No statistically significant differences in outcome measures were observed. A reoperation was performed in five patients in the autologous bone-graft group; one patient presented a rare malignant transformation from enchondroma to chondrosarcoma after the primary operation. No reoperations were performed in the BAG group.

Conclusion: Although AG is the gold standard for filling bony cavities, bone-graft retrieval can cause complications and postoperative pain. Our results suggest that S53P4 BAG is a safe and effective bone-graft material alternative for filling of enchondroma-evacuated cavities.

Keywords: Bioactive glass; bone graft; bone tumour; enchondroma.

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Conflict of interest statement

The Authors declare no potential conflicts of interest with respect to the research, authorship, and publication of this article. Nina Lindfors is a clinical advisor for BonAlive Biomaterials.

Figures

Figure 1
Figure 1. Flowchart of the patient data-retrieval process. AG: Autologous bone graft; BAG: bioactive glass; ICD-10 codes: International Statistical Classification of Diseases and Related Health Problems, 10th revision (14).
Figure 2
Figure 2. Plain radiographs from the case of a 35-year-old female with distal phalanx enchondroma at presentation (A), and at 3 months (B) and 1 year (C) after treatment with curettage and autogenous bone grafting.
Figure 3
Figure 3. Plain radiographs from the case of a 19-year-old female with middle phalanx enchondroma at presentation (A and B), and at 6 months after treatment with curettage and bioactive glass filling (C and D). A small amount of the bioactive glass can be seen to have drifted outside of the cavity without any clinical relevance (C).
See this image and copyright information in PMC

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