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. 2022 Nov;52(11):1551-1559.
doi: 10.1007/s00595-022-02505-8. Epub 2022 Apr 27.

Prognostic significance of preoperative low serum creatine kinase levels in gastric cancer

Nobuto Yamazaki  1   2 , Yoko Oshima  1   2 , Fumiaki Shiratori  1   2 , Tatsuki Nanami  2 , Takashi Suzuki  2 , Satoshi Yajima  2 , Kimihiko Funahashi  2 , Hideaki Shimada  3   4   5
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Prognostic significance of preoperative low serum creatine kinase levels in gastric cancer

Nobuto Yamazaki et al. Surg Today. 2022 Nov.

Abstract

Purpose: We evaluated the clinicopathological and prognostic significance of preoperative serum creatine kinase (CK) levels in gastric cancer.

Patients and methods: The subjects of this retrospective study were 942 patients who underwent surgery without preoperative chemotherapy for gastric cancer (643 men and 299 women), excluding Stage IV gastric cancer, between January, 2001 and December, 2020. We set the cutoff values for CK according to gender, as 64 U/L for men and 57 U/L for women, and evaluated the clinicopathological, prognostic, and gender significance of low CK levels by multivariate analysis.

Results: Tumor depth was significantly associated with low serum CK levels (p < 0.001). The low CK group showed significantly worse overall survival than the high CK group (p = 0.01). The prognostic impact of low CK levels was evident only in men (p = 0.009). In women, low CK levels were not an independent risk factor for poor prognosis (p = 0.33). These prognostic impacts of low CK levels on overall survival and recurrence-free survival were similar.

Conclusion: Low preoperative CK levels in men with gastric cancer were predictive of poor survival. These prognostic impacts of low CK levels were not evident in women.

Keywords: Creatine kinase; Gastric cancer; Gender; Prognosis.

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