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Review
. 2022 Apr 11:9:860375.
doi: 10.3389/fmolb.2022.860375. eCollection 2022.

Small Heat Shock Proteins in Retinal Diseases

Vivian Rajeswaren  1 , Jeffrey O Wong  1 , Dana Yabroudi  1 , Rooban B Nahomi  1 , Johanna Rankenberg  1 , Mi-Hyun Nam  1 , Ram H Nagaraj  1   2
Affiliations
Review

Small Heat Shock Proteins in Retinal Diseases

Vivian Rajeswaren et al. Front Mol Biosci. .

Abstract

This review summarizes the latest findings on small heat shock proteins (sHsps) in three major retinal diseases: glaucoma, diabetic retinopathy, and age-related macular degeneration. A general description of the structure and major cellular functions of sHsps is provided in the introductory remarks. Their role in specific retinal diseases, highlighting their regulation, role in pathogenesis, and possible use as therapeutics, is discussed.

Keywords: age-related macular degeneration; diabetic retinopathy; glaucoma; retina; small heat shock proteins.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
sHsps can inhibit or contribute to the pathogenesis of retinal diseases. This seemingly contradictory ability might depend on their cell type expression, response to stress and posttranslational modifications.
See this image and copyright information in PMC

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