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Clinical Trial
. 1987 Feb;9(2):147-53.
doi: 10.1016/s0272-6386(87)80092-6.

Reducing the hemorrhagic complications of hemodialysis: a controlled comparison of low-dose heparin and citrate anticoagulation

M J Flanigan, J Von Brecht, R M Freeman, V S Lim
Clinical Trial

Reducing the hemorrhagic complications of hemodialysis: a controlled comparison of low-dose heparin and citrate anticoagulation

M J Flanigan et al. Am J Kidney Dis. 1987 Feb.

Abstract

We report a randomized prospective study comparing the results of anticoagulation using hypertonic trisodium citrate and low-dose controlled heparin during 45 hemodialysis treatments performed on patients determined to be at high or very high risk for bleeding. Dialysis-associated bleeding was more frequent following low-dose controlled heparin anticoagulation than during hypertonic citrate therapy (P less than .05). Dialysis effectiveness measured by postdialysis chemistries and weight loss was equivalent in the two groups.

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