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. 2022 Aug;15(8):e202200059.
doi: 10.1002/jbio.202200059. Epub 2022 May 19.

Effects of photobiomodulation in experimental spinal cord injury models: A systematic review

Daysi da Cruz Tobelem  1 , Tamiris Silva  2 , Tamires Araujo  1 , Lucas Andreo  1 , Tainá Caroline Dos Santos Malavazzi  1 , Anna Carolina Ratto Tempestini Horliana  1 , Kristianne Porta Santos Fernandes  1 , Sandra Kalil Bussadori  1   2 , Raquel Agnelli Mesquita-Ferrari  1   2
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Effects of photobiomodulation in experimental spinal cord injury models: A systematic review

Daysi da Cruz Tobelem et al. J Biophotonics. 2022 Aug.

Abstract

This systematic review investigated the repercussions of photobiomodulation using low-level laser therapy (LLLT) for the treatment of spinal cord injury (SCI) in experimental models. Studies were identified from relevant databases published between January 2009 and December 2021. Nineteen original articles were selected and 68.4% used light at an infrared wavelength. There was a considerable variation of the power used (from 25 to 200 mW), total application time (8-3000 s) and total energy (0.3-450 J). In 79% of the studies, irradiation was initiated immediately after or within 2 h of the SCI, and treatment time ranged continuously from 5 to 21 days. In conclusion, LLLT can be an auxiliary therapy in the treatment of SCI, playing a neuroprotective role, enabling functional recovery, increasing the concentration of nerve connections around the injury site and reducing pro-inflammatory cytokines. However, there is a need for standardization in the dosimetric parameters.

Keywords: inflammation; low level laser therapy; photobiomodulation; spinal cord injury.

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