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Meta-Analysis
. 2022 Jul;31(6):1107-1123.
doi: 10.1177/10547738221092146. Epub 2022 Apr 28.

Prevalence of Sleep Disturbance in Patients With Cancer: A Systematic Review and Meta-Analysis

Mohammed Al Maqbali  1 , Mohammed Al Sinani  2   3 , Ahmad Alsayed  4 , Alexander M Gleason  5
Affiliations
Meta-Analysis

Prevalence of Sleep Disturbance in Patients With Cancer: A Systematic Review and Meta-Analysis

Mohammed Al Maqbali et al. Clin Nurs Res. 2022 Jul.

Abstract

Sleep disturbance is one of the most common and troubling symptoms that harm the quality of life throughout all phases of treatment and stages of the illness among patients with cancer. The aim of this meta-analysis is to examine the present status of sleep disturbance prevalence in patients with cancer. The following databases were searched: PubMed, CINAHL, MEDLINE, EMBASE, PsycINFO, from inception to April 2021. Prevalence rates were pooled with meta-analysis using a random-effects model. A total of 160 studies (N = 46,279) published between 1998 and 2021 met the inclusion criteria. The overall prevalence of sleep disturbance was 60.7% (26,448/46,279 participants, 95% CI 58.1-63.3%) with significant heterogeneity between studies (p < .000, τ2 = .0000, I2 = 96.4%). This meta-analysis highlights the importance of developing optimal monitoring strategies to reduce sleep disturbance and improve the quality of life of cancer patients.

Keywords: cancer; insomnia; meta-analysis; prevalence; sleep disturbance.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
PRISMA diagram.
Figure 2.
Figure 2.
Forest plot of the prevalence of sleep disturbance.
Figure 3.
Figure 3.
Funnel plot for assessing publication bias.
Figure 4.
Figure 4.
Adjusted funnel plot for assessing publication bias after adding 15 studies form the “trim and fill” analysis.
See this image and copyright information in PMC

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