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. 2022;122(4):31-35.
doi: 10.17116/jnevro202212204131.

[The use of vitamin B12 in cancer patients]

[Article in Russian]
N A Suponeva  1 , D A Grishina  1
Affiliations

[The use of vitamin B12 in cancer patients]

[Article in Russian]
N A Suponeva et al. Zh Nevrol Psikhiatr Im S S Korsakova. 2022.

Abstract
in English, Russian

Based on the data of foreign and domestic literature, the question of the possible carcinogenesis of vitamin B12 and the expediency of its administration to patients with cancer who have neurological complications due to chemotherapy is analyzed. The absence of convincing direct evidence of the carcinogenic effect of cyanocobalamin has been demonstrated, as well as the reasonableness of drug correction of vitamin B12 deficiency in cancer patients in order to prevent the development of characteristic deficient neurological disorders. The question of the effectiveness of oral administration of cyanocobalamin at a dose of 1 mg per day is considered.

На основании данных зарубежной и отечественной литературы проанализированы вопросы возможного канцерогенеза при применении витамина B12 и целесообразности его назначения пациентам с онкологическим заболеванием, имеющих неврологические осложнения вследствие химиотерапии. Продемонстрированы отсутствие убедительных прямых доказательств канцерогенного эффекта цианкобаламина, а также целесообразность медикаментозной коррекции дефицита витамина B12 у онкологических больных с целью предотвращения развития дефицитарных неврологических нарушений. Рассмотрен вопрос эффективности перорального приема цианкобаламина в дозе 1 мг/сут.

Keywords: cancer; carcinogenesis; chemotherapy; cyanocobalamin; deficiency; neurological disorders; oncology; oral administration; vitamin B12.

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