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. 2022 Sep;16(5):891-896.
doi: 10.1111/irv.12989. Epub 2022 Apr 29.

Clinical and socioeconomic burden of rhinoviruses/enteroviruses in the community

Katia Camille Halabi  1 , Melissa S Stockwell  1   2   3 , Luis Alba  1 , Celibell Vargas  1 , Carrie Reed  4 , Lisa Saiman  1   3 ; Mobile Surveillance for Acute Respiratory Infection/Influenza-like Illness in the Community (MoSAIC) Study Team
Affiliations

Clinical and socioeconomic burden of rhinoviruses/enteroviruses in the community

Katia Camille Halabi et al. Influenza Other Respir Viruses. 2022 Sep.

Abstract

Background: The epidemiology, clinical features, and socioeconomic burden associated with detection of rhinoviruses (RV)/enteroviruses (EV) from individuals in the community with acute respiratory infections (ARIs) are not fully understood.

Methods: To assess the clinical and socioeconomic burden associated with RV/EV, a secondary analysis of data collected during a prospective, community-based ARI surveillance study was performed. From December 2012 to September 2017, adult and pediatric participants with ARIs had nasopharyngeal specimens obtained and tested by multiplex polymerase chain reaction assay. Characteristics and socioeconomic burden including missed school or work and/or antibiotic use among participants who did and did not seek medical care and among participants with and without co-detection of another respiratory pathogen with RV/EV were compared.

Results: Throughout the study period, RV/EV was detected in 54.7% (885/1617) of ARIs with a respiratory pathogen detected. Most ARI episodes associated with RV/EV occurred in females (59.1%) and children ≤17 years old (64.2%). Those ≤17 years were more likely to seek medical care. Compared to those not seeking medical care (n = 686), those seeking medical care (n = 199) had a longer duration of illness (5 vs. 7 days) and were more likely to miss work/school (16.4% vs. 47.7%) and/or use antibiotics (3.6% vs. 34.2%). Co-detection occurred in 8% of ARIs of which 81% occurred in children. Co-detection was not associated with longer illness, more missed work/or school, or antibiotic use.

Conclusion: Non-medically attended and medically attended ARIs associated with RV/EV resulted in clinical and socioeconomic burden, regardless of co-detection of other respiratory pathogens.

Keywords: antibiotic stewardship; clinical burden; community surveillance; enterovirus; rhinovirus; socioeconomic burden.

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Figures

FIGURE 1
FIGURE 1
Seasonal epidemiology of rhinoviruses/enteroviruses (RV/EV) detection associated with ARIs. The number of acute respiratory infections (ARIs) with RV/EV detected monthly in adults ≥18 years old, children ≤17 years old, and all participants are shown from December 2012 to September 2017 with peaks in early spring and early fall
See this image and copyright information in PMC

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