Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 May 1;50(5):e502-e503.
doi: 10.1097/CCM.0000000000005484. Epub 2022 Apr 11.

The authors reply

Tatiana Barichello  1   2 , Tarek Sharshar  3   4   5 , Felipe Dal-Pizzol  1
Affiliations
Comment

The authors reply

Tatiana Barichello et al. Crit Care Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Dr. Barichello received support for article research from the National Institutes of Health. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Figures

Figure 1.
Figure 1.
Influence of the microbiota-gut-brain axis on inflammatory and immune response after sepsis. The diagram depicts the many alterations observed in preclinical and clinical sepsis compared with healthy controls. The up-arrow shows a rise in the relative mechanism, while the down-arrow represents a drop. BBB = blood-brain barrier, SCFAs = short-chain fatty acids, TRYP = tryptophan metabolites.
See this image and copyright information in PMC

Comment on

References

    1. Xu R, Miao L, Yang C, et al.: Key Role of Gut Microbiota in Neuroinflammation of Septic Patients. Crit Care Med 2022; 50:e500–e501 - PubMed
    1. Barichello T, Generoso JS, Dominguini D, et al.: Postmortem evidence of brain inflammatory markers and injury in septic patients: A systematic review. Crit Care Med 2022; 50:e241–e252 - PubMed
    1. Cryan JF, O’Riordan KJ, Cowan CSM, et al.: The microbiota-gut-brain axis. Physiol Rev 2019; 99:1877–2013 - PubMed
    1. Rothhammer V, Quintana FJ: The aryl hydrocarbon receptor: An environmental sensor integrating immune responses in health and disease. Nat Rev Immunol 2019; 19:184–197 - PubMed
    1. Adelman MW, Woodworth MH, Langelier C, et al.: The gut microbiome’s role in the development, maintenance, and outcomes of sepsis. Crit Care 2020; 24:278. - PMC - PubMed