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Clinical Trial
. 1987 Feb;30(2):218-20.
doi: 10.1002/art.1780300213.

Lack of association between HLA-DR2 and clinical response to methotrexate in patients with rheumatoid arthritis

G S Alarcón, L M Billingsley, D O Clegg, J G Hardin, J Klippel, M E Luggen, R P Polisson, J Z Singer, L Szydlo, R F Willkens, et al.
Clinical Trial

Lack of association between HLA-DR2 and clinical response to methotrexate in patients with rheumatoid arthritis

G S Alarcón et al. Arthritis Rheum. 1987 Feb.

Abstract

Recent studies have indicated an association between the HLA-DR2 phenotype and substantial response to methrotrexate in patients with rheumatoid arthritis (RA). To further resolve this issue, we analyzed this relationship. Our data, obtained from a multicenter, double-blind study of rigorously assessed patients with RA, demonstrated that neither HLA-DR2 nor any other HLA-DR specificity is significantly associated with a substantial clinical response to methotrexate in patients with RA.

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