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. 1987 Feb;23(2):229-33.
doi: 10.1111/j.1365-2125.1987.tb03034.x.

Metabolism of azathioprine to 6-thioguanine nucleotides in patients with pemphigus vulgaris

L Lennard, C I Harrington, M Wood, J L Maddocks

Metabolism of azathioprine to 6-thioguanine nucleotides in patients with pemphigus vulgaris

L Lennard et al. Br J Clin Pharmacol. 1987 Feb.

Abstract

Azathioprine metabolism, to red cell 6-thioguanine nucleotides (6TGN), was studied in four patients with pemphigus vulgaris. Throughout treatment blood samples were taken for red cell 6TGN assay and differential white cell counts. Metabolite steady-state occurred in three patients in 2, 2 and 4 months respectively. In the fourth patient red cell 6TGN concentrations increased slowly over 3 years. There was a significant negative correlation between 6TGN concentrations and the white blood cell count (rs = -0.92, P less than 0.0005) in this patient.

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References

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