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. 2022 May;37(5):1215-1221.
doi: 10.1007/s00384-022-04153-3. Epub 2022 Apr 29.

Application of PREVENA (Surgical Incision Protection System) in reducing surgical site infections following reversal of ileostomy or colostomy: the PRIC study protocol

Ernest Z Low  1 , Timothy S Nugent  2 , Niall J O'Sullivan  3 , Dara Kavanagh  3 , John O Larkin  2 , Paul H McCormick  2 , Brian J Mehigan  2 , Michael E Kelly  2
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Application of PREVENA (Surgical Incision Protection System) in reducing surgical site infections following reversal of ileostomy or colostomy: the PRIC study protocol

Ernest Z Low et al. Int J Colorectal Dis. 2022 May.

Abstract

Aim: There is a current lack of evidence in the literature to support the routine use of negative pressure wound therapy (NPWT) to reduce the risk of surgical site infections (SSI) in the setting of ileostomy or colostomy reversal. The aim of this study is to examine whether routine NPWT confers a lower rate of SSI than conventional dressings following reversal of ileostomy or colostomy.

Methods: The PRIC study is a randomized, controlled, open-label, multi-centre superiority trial to assess whether routine NPWT following wound closure confers a lower rate of SSI following reversal of ileostomy or colostomy when compared to conventional dressings. Participants will be consecutively identified and recruited. Eligible participants will be randomized in a 1:1 allocation ratio, to receive either the NPWT (PREVENA) dressings or conventional dressings which will be applied immediately upon completion of surgery. PREVENA dressings will remain applied for a duration of 7 days. Surgical wounds will then be examined on post-operative day seven as well as during follow-up appointments in OPD for any evidence of SSI. In the interim, public health nurses (PHN) will provide out-patient support services incorporating wound assessment and care as part of a routine basis. Study investigators will liaise with PHN to gather the relevant data in relation to the time to wound healing. Our primary endpoint is the incidence of SSI within 30 days of stoma reversal. Secondary endpoints include measuring time to wound healing, evaluating wound healing and aesthetics and assessing patient satisfaction.

Conclusion: The PRIC study will assess whether routine NPWT following wound closure is superior to conventional dressings in the reduction of SSI following reversal of ileostomy or colostomy and ascertain whether routine NPWT should be considered the new standard of care.

Keywords: Colorectal surgery; Colostomy; Ileostomy; Negative pressure dressings; PREVENA therapy; Reversal surgery; Surgical site infection.

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Conflict of interest statement

The authors declare no competing interests.

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References

    1. Sherman KL, Wexner SD (2017) Considerations in Stoma Reversal. Clin Colon Rectal Surg 30(3):172–177. 10.1055/s-0037-1598157. Epub 2017 May 22. PMID: 28684934; PMCID: PMC5498167 - PMC - PubMed
    1. Kartal K, Citgez B, Koksal MH, Besler E, Akgun İE, Mihmanli M. Colostomy reversal after a Hartmann's procedure Effects of experience on mortality and morbidity. Ann Ital Chir. 2019;90:539–544. - PubMed
    1. Gheorghe A, Moran G, Duffy H, Roberts T, Pinkney T, Calvert M. Health Utility Values Associated with Surgical Site Infection: A Systematic Review. Value Health. 2015;18(8):1126–1137. doi: 10.1016/j.jval.2015.08.004. - DOI - PubMed
    1. Badia JM, Casey AL, Petrosillo N, Hudson PM, Mitchell SA, Crosby C. Impact of surgical site infection on healthcare costs and patient outcomes: a systematic review in six European countries. J Hosp Infect. 2017;96(1):1–15. doi: 10.1016/j.jhin.2017.03.004. - DOI - PubMed
    1. Hsieh MC, Kuo LT, Chi CC, Huang WS, Chin CC. Pursestring Closure versus Conventional Primary Closure Following Stoma Reversal to Reduce Surgical Site Infection Rate: A Meta-analysis of Randomized Controlled Trials. Dis Colon Rectum. 2015;58(8):808–815. doi: 10.1097/DCR.0000000000000401. - DOI - PubMed

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