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. 2022 Apr 29;14(1):60.
doi: 10.1186/s13098-022-00832-x.

The association between diabetes coexisting with low levels of high-density lipoprotein cholesterol and peritoneal dialysis-related peritonitis

Rui Zhang #  1 , Xing Zhang #  1 , Xingming Tang  2 , Liwen Tang  2 , Sijia Shang  1 , Xiaoyang Wang  3 , Yueqiang Wen  4 , Xiaoran Feng  5 , Qian Zhou  6 , Ning Su  7 , Yajuan Huang  8
Affiliations

The association between diabetes coexisting with low levels of high-density lipoprotein cholesterol and peritoneal dialysis-related peritonitis

Rui Zhang et al. Diabetol Metab Syndr. .

Abstract

Background: Low levels of high-density lipoprotein cholesterol (HDL-C) and diabetes are common in patients undergoing peritoneal dialysis (PD). The aim of this study was to investigate the association between the coexistence of diabetes with a low level of HDL-C and the first episode of peritoneal dialysis-related peritonitis (PDRP) in patients with PD.

Methods: We retrospectively investigated patients with PD from January 1, 2003, to May 31, 2020, in four PD centers. Patients with PD were divided into four groups: no comorbidities, low HDL-C only, diabetes only, and diabetes plus low HDL-C. The clinical and laboratory baseline data of the four groups were collected and compared. The association between diabetes coexisting with low HDL-C levels and the first episode of PDRP was analyzed by multivariate Cox regression analysis.

Results: A total of 1013 patients with PD were included in our study. The mean age was 49.94 ± 14.32 years, and 597 (58.99%) patients were males. A total of 301 (29.7%) patients had their first episodes of PDRP, and low HDL-C levels coexisted with diabetes in 72 patients with PD. After adjusting for confounding factors, a low level of HDL-C coexisting with diabetes was significantly associated with the first episode of PDRP in our study (hazard ratio: 2.81, 95% CI 1.32 ~ 4.73, p = 0.005). The associations among HDL-C, diabetes and PDRP were consistent in the following subgroups: sex, age, and pre-existing CVD (all P interaction > 0.05).

Conclusions: Patients with both diabetes and low HDL-C levels were at higher risk for PDRP in patients with PD.

Keywords: Diabetes; High-density lipoprotein cholesterol; Infection; Peritoneal dialysis; Peritonitis.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Process of patients inclusion
Fig. 2
Fig. 2
Kaplan–Meier curve of overall peritonitis-free survival
Fig. 3
Fig. 3
Subgroup analysis of gender, age and pre-existing cardiovascular disease
See this image and copyright information in PMC

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