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Review
. 2022 Jun;24(6):944-958.
doi: 10.1002/ejhf.2522. Epub 2022 May 16.

Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Alberto Aimo  1   2 , Giuseppe Vergaro  1   2 , Arantxa González  3   4 , Andrea Barison  1   2 , Josep Lupón  5 , Victoria Delgado  5 , A Mark Richards  6 , Rudolf A de Boer  7 , Thomas Thum  8   9 , Henrike Arfsten  8   9 , Martin Hülsmann  8 , Inês Falcao-Pires  10 , Javier Díez  11 , Roger S Y Foo  12 , Mark Yan Yee Chan  12 , Chukwuemeka G Anene-Nzelu  12 , Magdy Abdelhamid  13 , Stamatis Adamopoulos  14 , Stefan D Anker  15 , Yuri Belenkov  16 , Tuvia Ben Gal  17 , Alain Cohen-Solal  18 , Michael Böhm  19 , Ovidiu Chioncel  20 , Ewa A Jankowska  21 , Finn Gustafsson  22 , Loreena Hill  23 , Tiny Jaarsma  24 , James L Januzzi  25 , Pardeep Jhund  26 , Yuri Lopatin  27 , Lars H Lund  28 , Marco Metra  29 , Davor Milicic  30 , Brenda Moura  10   31 , Christian Mueller  32 , Wilfried Mullens  33 , Julio Núñez  34 , Massimo F Piepoli  35 , Amina Rakisheva  36 , Arsen D Ristić  37   38 , Patrick Rossignol  39 , Gianluigi Savarese  28 , Carlo G Tocchetti  40 , Sophie van Linthout  41 , Maurizio Volterrani  42 , Petar Seferovic  38   43 , Giuseppe Rosano  44 , Andrew J S Coats  45 , Michele Emdin  1   2 , Antoni Bayes-Genis  4   5   46
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Free article
Review

Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Alberto Aimo et al. Eur J Heart Fail. 2022 Jun.
Free article

Erratum in

Abstract

In patients with heart failure, the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with heart failure with reduced ejection fraction because most studies on cardiac remodelling focused on this setting.

Keywords: Biomarkers; Ejection fraction; Heart failure; Imaging; Predictors; Remodelling; Therapies.

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