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Observational Study
. 2022 Aug;407(5):2021-2026.
doi: 10.1007/s00423-022-02518-4. Epub 2022 Apr 30.

High visceral to subcutaneous fat area ratio predicts early postoperative small bowel obstruction after surgery for colorectal cancer

Yuki Nakamura  1 , Kenji Matsuda  2 , Shozo Yokoyama  1 , Hiromitsu Iwamoto  1 , Yuki Mizumoto  1 , Yasuyuki Mitani  1 , Yoshimasa Oku  1 , Hiroki Yamaue  1
Affiliations
Observational Study

High visceral to subcutaneous fat area ratio predicts early postoperative small bowel obstruction after surgery for colorectal cancer

Yuki Nakamura et al. Langenbecks Arch Surg. 2022 Aug.

Abstract

Purpose: Risks for postoperative small bowel obstruction have been demonstrated in several reports, most of which indicated male sex was a risk factor, but with the reason remaining unknown. We tested the hypothesis that it could be because males have more visceral fat than females. This prospective observational study aims to examine risks of early postoperative small bowel obstruction (EPSBO) after colorectal cancer surgery and the association between visceral to subcutaneous fat area ratio (V/S ratio) and EPSBO.

Methods: Four hundred and seventy-four patients who underwent colectomy for colorectal cancer in our hospital were enrolled in this study. The influence of several factors including V/S ratio on the development of EPSBO was analyzed.

Results: Thirty-one of the 474 patients (6.5%) developed EPSBO. EPSBO occurred more frequently in males (p = 0.03) and cases who developed postoperative anastomotic leakage (p < 0.001) or wound infection (p = 0.02). Higher V/S ratio was strongly related to male sex (p < 0.001). Multivariate analysis revealed higher V/S ratio (OR 2.25; p = 0.049) and anastomotic leakage (OR 5.86; p < 0.001) were independent risk factors for EPSBO.

Conclusion: Higher V/S ratio was significantly related to EPSBO, suggesting that one of the reasons EPSBO was more likely to occur in males because they have more visceral fat than females. Preoperative identification of this risk factor could help us watch out for this potential complication.

Keywords: Colectomy; Colorectal cancer; Early postoperative small bowel obstruction; Visceral to subcutaneous fat area ratio.

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