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Case Reports
. 2022 Jul:57:236.e5-236.e6.
doi: 10.1016/j.ajem.2022.04.028. Epub 2022 Apr 25.

Missed abortion with negative biomarkers

Robert Allen  1 , Allison Lee  2 , Christopher Hanuscin  2 , Aleksandr Gleyzer  2
Affiliations
Case Reports

Missed abortion with negative biomarkers

Robert Allen et al. Am J Emerg Med. 2022 Jul.

Abstract

Background: First-trimester bleeding and pregnancy loss are common reasons for presentation to emergency departments. Women of childbearing age frequently receive urine and serum pregnancy tests, which are thought to be reliable markers of pregnancy.

Case presentation: We report a case of a 34-year-old woman who presented to an emergency department with vaginal bleeding and abdominal pain and was found to have negative urine and serum markers of pregnancy. A transvaginal ultrasound detected non-viable fetal tissue and the patient underwent an uncomplicated spontaneous abortion.

Conclusions: Physicians should consider the use of ultrasonography to assess for pregnancy or retained fetal products in the appropriate patient, even with negative serum or urine markers of pregnancy.

Keywords: Gynecology; Ultrasonography.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no competing interests. RA drafted the manuscript, and all authors contributed substantially to its revision. RA takes responsibility for the paper as a whole.

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