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. 2022 Jul:63:103830.
doi: 10.1016/j.msard.2022.103830. Epub 2022 Apr 25.

Faster B-cell repletion after anti-CD20 infusion in Black patients compared to white patients with neurologic diseases

Lucia Saidenberg  1 , Arnaldo A Arbini  2 , Gregg J Silverman  3 , Itay Lotan  4 , Gary Cutter  5 , Ilya Kister  6
Affiliations

Faster B-cell repletion after anti-CD20 infusion in Black patients compared to white patients with neurologic diseases

Lucia Saidenberg et al. Mult Scler Relat Disord. 2022 Jul.

Abstract

This retrospective, single-center study aimed to characterize and compare the kinetics of B-cell reemergence following anti-CD20 infusion (anti-CD20i) in African American (AA) and white patients with MS or NMOSD. In a logistic regression model that included race, time since anti-CD20i, body mass index, and diagnosis, only AA race (p=0.01) and time since anti-CD20i (p=0.0003) were significant predictors of B-cell repletion. However, B-cell subset composition was similar between AA and white patients with detectable CD19+ B-cell counts. These findings highlight the importance of including a diverse study population in future studies of anti-CD20 therapies.

Keywords: anti-CD20; b-cell repletion; multiple sclerosis; neuromyelitis optica; ocrelizumab; race; rituximab.

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