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Editorial
. 2022 Aug;150(2):299-301.
doi: 10.1016/j.jaci.2022.04.022. Epub 2022 Apr 28.

A "LEAP" forward in understanding immune mechanisms of oral tolerance to peanut

Timothy P Moran  1 , Michael D Kulis  2
Affiliations
Editorial

A "LEAP" forward in understanding immune mechanisms of oral tolerance to peanut

Timothy P Moran et al. J Allergy Clin Immunol. 2022 Aug.
No abstract available

Keywords: CTLA-4; Peanut allergy; oral tolerance; regulatory T cells.

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Conflict of interest statement

Disclosure of potential conflict of interest: M. D. Kulis receives consulting fees from UKKO. The remaining author declares that he has no relevant conflicts of interest.

Figures

FIG 1.
FIG 1.
Ingestion of peanut induces CTLA-4-expressing Treg cells that protect mice from peanut allergy caused by environmental peanut exposure. During peanut avoidance, exposure to environmental peanut through the airway or skin results in increased numbers of IL-4–producing follicular helper T (TFH) cells and germinal center (GC) B cells in tissue-draining lymph nodes, leading to increased levels of peanut-specific immunoglobulins and development of peanut allergy. In contrast, peanut consumption induces a Treg cell population that expresses high-levels of CTLA-4, which suppress TFH and GC B-cell expansion following environmental peanut exposure. This results in decreased production of peanut-specific immunoglobulins and development of tolerance to peanut. Created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

    1. Sicherer SH, Sampson HA. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol 2018;141:41–58. - PubMed
    1. Kulis MD, Smeekens JM, Immormino RM, Moran TP. The airway as a route of sensitization to peanut: an update to the dual allergen exposure hypothesis. J Allergy Clin Immunol 2021;148:689–93. - PMC - PubMed
    1. Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med 2015;372:803–13. - PMC - PubMed
    1. Du Toit G, Sayre PH, Roberts G, Sever ML, Lawson K, Bahnson HT, et al. Effect of avoidance on peanut allergy after early peanut consumption. N Engl J Med 2016;374:1435–43. - PMC - PubMed
    1. Togias A, Cooper SF, Acebal ML, Assa’ad A, Baker JR Jr, Beck LA, et al. Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol 2017;139:29–44. - PMC - PubMed

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