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Editorial
. 2022 May 2;12(5):1184-1186.
doi: 10.1158/2159-8290.CD-22-0219.

Converting Tumoral PD-L1 into a 4-1BB Agonist for Safer and More Effective Cancer Immunotherapy

Zihai Li  1   2 , Joseph H Azar  1   2 , Mark P Rubinstein  1   2
Affiliations
Editorial

Converting Tumoral PD-L1 into a 4-1BB Agonist for Safer and More Effective Cancer Immunotherapy

Zihai Li et al. Cancer Discov. .

Abstract

Dose-limiting toxicities are thought to temper the efficacy of single-agent 4-1BB agonists. To overcome this hurdle, in this issue of Cancer Discovery, Muik and colleagues report preclinical and clinical studies describing a first-in-class bispecific fusion protein targeting 4-1BB and PD-L1. See related article by Muik et al., p. 1248 (9).

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