Innovative methodologies in paediatric drug development: A conect4children (c4c) special issue

Saskia N de Wildt^{1

2}, Ian C K Wong^{3

4}

Affiliations

¹ Department of Pharmacology and Toxicology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
² Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
³ Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
⁴ Research Department of Practice and Policy, UCL, School of Pharmacy, London, UK.

Free article

Editorial

Saskia N de Wildt et al. Br J Clin Pharmacol. 2022 Dec.

Free article

. 2022 Dec;88(12):4962-4964.

doi: 10.1111/bcp.15355. Epub 2022 May 2.

Saskia N de Wildt^{1

2}, Ian C K Wong^{3

4}

¹ Department of Pharmacology and Toxicology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.
² Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
³ Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing, Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
⁴ Research Department of Practice and Policy, UCL, School of Pharmacy, London, UK.

No abstract available

References

1. Weda M, Hoebert J, Vervloet M, et al. Study on off-label use of medicinal products in the European Union. Luxembourg: Publications Office of the European Union; 2017.
1. European Commission. State of Paediatric Medicines in the EU: 10 years of the EU Paediatric Regulation. Published 2017. Accessed March 8, 2022. https://ec.europa.eu/health/system/files/2017-11/2017_childrensmedicines...
1. conect4children. Collaborative Netwerk for European Clinical Trials for Children. Published 2018. Accessed March 8, 2022. https://www.conect4children.org
1. Smits A, Annaert P, Cavallaro G, et al. Current knowledge, challenges and innovations in developmental pharmacology: a combined conect4children Expert Group and European Society for Developmental, Perinatal and Paediatric Pharmacology White Paper. Br J Clin Pharmacol. 2022;88(12):4965-4984. doi:10.1111/bcp.14958
1. Bouazza N, Dokoumetzidis A, Knibbe CAJ, et al. General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimisation of study protocols for small molecules and monoclonal antibodies in children. Br J Clin Pharmacol. 2022;88(12):4985-4996. doi:10.1111/bcp.15571