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Review
. 2022 Apr 15:9:883727.
doi: 10.3389/fmed.2022.883727. eCollection 2022.

The Role of Quantitative and Semi-quantitative [18F]FDG-PET/CT Indices for Evaluating Disease Activity and Management of Patients With Dermatomyositis and Polymyositis

Halil Yildiz  1 , Philippe D'abadie  2 , Olivier Gheysens  2
Affiliations
Review

The Role of Quantitative and Semi-quantitative [18F]FDG-PET/CT Indices for Evaluating Disease Activity and Management of Patients With Dermatomyositis and Polymyositis

Halil Yildiz et al. Front Med (Lausanne). .

Abstract

Idiopathic inflammatory myopathies (IIM) are considered systemic diseases involving different organs and some subtypes are associated with increased cancer risk. In this review, we provide a comprehensive summary of the current use and potential applications of (semi-)quantitative [18F]FDG-PET/CT indices in patients with IIM focusing on dermatomyositis and polymyositis. Visual interpretation and (semi-)quantitative [18F]FDG-PET indices have a good overall performance to detect muscle activity but objective, robust and standardized interpretation criteria are currently lacking. [18F]FDG-PET/CT is a suitable modality to screen for malignancy in patients with myositis and may be a promising tool to detect inflammatory lung activity and to early identify patients with rapidly progressive lung disease. The latter remains to be determined in large, prospective comparative trials.

Keywords: [18F]FDG-PET/CT; cancer; dermatomyositis; interstitial lung disease; polymyositis; standardized uptake value.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram.
Figure 2
Figure 2
Representative [18F]FDG-PET images in a control patient and a patient with dermatomyositis. [18F]FDG-PET maximum intensity projection image of a subject with physiologic [18F]FDG biodistribution (A) and a representative patient with dermatomyositis (B). Proximal and symmetrical heterogeneous [18F]FDG muscle uptake is observed in patient (B).
See this image and copyright information in PMC

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