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. 2022 Apr 22:14:249-264.
doi: 10.2147/CEOR.S350790. eCollection 2022.

Cost-Effectiveness Analysis of Fracture Liaison Services Compared with Standard of Care in the Secondary Prevention of Fragility Fractures in Spain

Antonio Naranjo  1 , Daniel Prieto-Alhambra  2 , Julián Sánchez-Martín  3 , Alejandro Pérez-Mitru  3 , Max Brosa  3
Affiliations

Cost-Effectiveness Analysis of Fracture Liaison Services Compared with Standard of Care in the Secondary Prevention of Fragility Fractures in Spain

Antonio Naranjo et al. Clinicoecon Outcomes Res. .

Abstract

Purpose: To assess the cost-effectiveness of a Fracture Liaison Service (FLS) compared with standard care for the secondary prevention of fragility fractures in Spain.

Methods: Patients with osteoporosis and an initial fragility fracture who were candidates to initiate osteoporosis treatment (mean age 65 years, 90.7% female) were included in the model. Disease progression was simulated with a Markov model through seven health states (with and without osteoporosis treatment, subsequent hip, vertebral, forearm and humerus fracture, and death). A time horizon of 10 years and a 6-month duration per cycle was set. Clinical, economic, and quality of life parameters were estimated from the literature and Spanish clinical practice. Resource use and treatment patterns were validated by an expert panel. The Spanish National Health System (SNS) perspective was adopted, taking direct costs (€; 2020) into account. Effectiveness was measured in life-years gained (LYG) and quality-adjusted life years gained (QALYs). A discount rate of 3% was applied to costs and outcomes. The uncertainty of the parameters was assessed using deterministic, scenario and probabilistic sensitivity analyses (1000 iterations).

Results: Setting up a FLS for the secondary prevention of fragility fractures in Spain would provide better osteoporosis treatment initiation and persistence. This would reduce subsequent fragility fractures, disutilities and deaths. FLS would have greater clinical benefits (0.008 and 0.082 LYG and QALY gained per patient, respectively) and higher costs (€563.69 per patient) compared with standard care, leading to an incremental cost-utility ratio of €6855.23 per QALY gained over the 10 years horizon. The sensitivity analyses showed limited dispersion of the base case results, corroborating their robustness.

Conclusion: From the SNS perspective and considering Spanish willingness-to-pay thresholds, the introduction of FLS for the secondary prevention of fragility fractures would be a cost-effective strategy.

Keywords: Spain; economic evaluation; fracture liaison service; osteoporotic fracture prevention.

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Conflict of interest statement

AN and DPA are employed by the Hospital Universitario de Gran Canaria Dr. Negrín (University of Las Palmas de Gran Canaria) and NIHR Musculoskeletal Biomedical Research Unit (University of Oxford), respectively. AN reports grants and/or personal fees for consulting/speaker bureau fee from Amgen, Lilly and UCB. DPA reports grants for speaker services and advisory board membership from AMGEN, fees for consultancy services to his department from UCB Biopharma and Astra Zeneca, grants from Les Laboratoires Servier, EMA, Chesi-Taylor, and Novartis, outside the submitted work; Janssen, on behalf of IMI-funded EHDEN and EMIF consortiums, and Synapse Management Partners have supported training programmes organised by DPA’s department and open for external participants. APM, JSM and MB are employees of Pharmalex Spain, an independent contracting health economic organization which received consultancy fees from Fundación Canaria Instituto de Investigación Sanitaria de Canarias. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Model structure. (A) decision tree. (B) Markov model.
Figure 2
Figure 2
Tornado diagram.
Figure 3
Figure 3
Incremental cost-effectiveness plane resulting from probabilistic sensitivity analysis.
See this image and copyright information in PMC

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