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Comment
. 2022 Mar 15;3(3):100578.
doi: 10.1016/j.xcrm.2022.100578.

FGF21 regulates alcohol intake: New hopes on the rise for alcohol use disorder treatment?

Tammy Wang  1 , Mehdi Farokhnia  1 , Lorenzo Leggio  1
Affiliations
Comment

FGF21 regulates alcohol intake: New hopes on the rise for alcohol use disorder treatment?

Tammy Wang et al. Cell Rep Med. .

Abstract

FGF21 is a liver-derived hormone primarily involved in glucose/lipid metabolism. A recent study by Flippo and colleagues1 demonstrates that administration of FGF21 or an FGF21 analog suppresses alcohol consumption in rodents and non-human primates, likely through an amygdalo-striatal circuit.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Schematic outline of the potential bidirectional relationship between FGF21 and alcohol use BLA, basolateral amygdala; FGF21, fibroblast growth factor 21.
See this image and copyright information in PMC

Comment on

  • FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit.
    Flippo KH, Trammell SAJ, Gillum MP, Aklan I, Perez MB, Yavuz Y, Smith NK, Jensen-Cody SO, Zhou B, Claflin KE, Beierschmitt A, Fink-Jensen A, Knop FK, Palmour RM, Grueter BA, Atasoy D, Potthoff MJ. Flippo KH, et al. Cell Metab. 2022 Feb 1;34(2):317-328.e6. doi: 10.1016/j.cmet.2021.12.024. Cell Metab. 2022. PMID: 35108517 Free PMC article.

References

    1. Flippo K.H., Trammell S.A.J., Gillum M.P., Aklan I., Perez M.B., Yavuz Y., Smith N.K., Jensen-Cody S.O., Zhou B., Claflin K.E., et al. FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit. Cell Metab. 2022;34:317–328.e6. doi: 10.1016/j.cmet.2021.12.024. - DOI - PMC - PubMed
    1. Kenna G.A., Swift R.M., Hillemacher T., Leggio L. The relationship of appetitive, reproductive and posterior pituitary hormones to alcoholism and craving in humans. Neuropsychol. Rev. 2012;22:211–228. doi: 10.1007/s11065-012-9209-y. - DOI - PMC - PubMed
    1. Spann R.A., Morrison C.D., den Hartigh L.J. The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model. Front. Endocrinol. (Lausanne) 2022;12:802541. doi: 10.3389/fendo.2021.802541. - DOI - PMC - PubMed
    1. Søberg S., Andersen E.S., Dalsgaard N.B., Jarlhelt I., Hansen N.L., Hoffmann N., Vilsbøll T., Chenchar A., Jensen M., Grevengoed T.J., et al. FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest. Mol. Metab. 2018;11:96–103. doi: 10.1016/j.molmet.2018.03.010. - DOI - PMC - PubMed
    1. Wagner-Skacel J., Horvath A., Grande P., Wenninger J., Matzer F., Fazekas C., Mörkl S., Meinitzer A., Stadlbauer V. Association of fibroblast growth factor 21 with alcohol consumption and alcohol liver cirrhosis. Neuropsychiatr. 2021;35:140–146. doi: 10.1007/s40211-020-00380-8. - DOI - PMC - PubMed

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