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. 2022 Jan 5:7:5.
doi: 10.12688/wellcomeopenres.17468.1. eCollection 2022.

Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data

Martin Walker #  1   2   3 , Luzia T Freitas #  1   2   3 , Julia B Halder #  1   2   3 , Matthew Brack  3 , Jennifer Keiser  4   5 , Charles H King  6 , Bruno Levecke  7 , Yvonne Ai-Lian Lim  8 , Otavio Pieri  9 , Doudou Sow  10 , J Russell Stothard  11 , Joanne P Webster  1   2 , Xiao-Nong Zhou  12 , Robert F Terry  13 , Philippe J Guérin  3 , Maria-Gloria Basáñez  2   3
Affiliations

Improving anthelmintic treatment for schistosomiasis and soil-transmitted helminthiases through sharing and reuse of individual participant data

Martin Walker et al. Wellcome Open Res. .

Abstract

The Infectious Diseases Data Observatory (IDDO, https://www.iddo.org) has launched a clinical data platform for the collation, curation, standardisation and reuse of individual participant data (IPD) on treatments for two of the most globally important neglected tropical diseases (NTDs), schistosomiasis (SCH) and soil-transmitted helminthiases (STHs). This initiative aims to harness the power of data-sharing by facilitating collaborative joint analyses of pooled datasets to generate robust evidence on the efficacy and safety of anthelminthic treatment regimens. A crucial component of this endeavour has been the development of a Research Agenda to promote engagement with the SCH and STH research and disease control communities by highlighting key questions that could be tackled using data shared through the IDDO platform. Here, we give a contextual overview of the priority research themes articulated in the Research Agenda-a 'living' document hosted on the IDDO website-and describe the three-stage consultation process behind its development. We also discuss the sustainability and future directions of the platform, emphasising throughout the power and promise of ethical and equitable sharing and reuse of clinical data to support the elimination of NTDs.

Keywords: anthelmintic; data reuse; data sharing; neglected tropical diseases; schistosomiasis; soil-transmitted helminthiasis; treatment.

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Conflict of interest statement

No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. The Infectious Diseases Data Observatory (IDDO) Research Agenda development process.
Schematic reproduced with permission from https://www.iddo.org/research-agenda-development-process.
See this image and copyright information in PMC

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