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. 1986;48(2-3):297-300.
doi: 10.1016/0378-1119(86)90089-2.

Structure and activity of the translocated c-myc in mouse plasmacytoma XRPC-24

B Moav, M Horowitz, J B Cohen, G Rechavi, E Eliyahu, M Oren, D Givol

Structure and activity of the translocated c-myc in mouse plasmacytoma XRPC-24

B Moav et al. Gene. 1986.

Abstract

In the mouse plasmacytoma XRPC-24 both c-mos and c-myc are rearranged. We cloned the rearranged c-myc and found that it was translocated to the immunoglobulin C alpha locus. The breakpoint is at the end of exon 1 in c-myc and approximately 0.5 kb upstream from exon 1 of C alpha. The cloned translocated c-myc linked to a strong transcriptional promoter can efficiently transform rat embryo fibroblasts when co-transfected with the activated Ha-ras. The transformed cells are tumorigenic in syngeneic rats.

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