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. 2021 Oct 27;11(55):34820-34827.
doi: 10.1039/d1ra03268b. eCollection 2021 Oct 25.

Novel potentiometric sensors for determination of ondansetron hydrochloride in pure and dosage form

Amina M Abass  1 , Sahar S M Alabdullah  1   2 , Omar Salih Hassan  3 , Ahmed Ahmed  1
Affiliations

Novel potentiometric sensors for determination of ondansetron hydrochloride in pure and dosage form

Amina M Abass et al. RSC Adv. .

Abstract

A new and sensitive potentiometric method has been developed and characterized for four novel sensors responsive to ondansetron hydrochloride. The potentiometric sensor method includes advancement of ondansetron hydrochloride sensors using a membrane comprised of molybdophosphoric acid (MPA) and ondansetron as an electro-active material in a polyvinylchloride (PVC) matrix membrane plasticized with di-butyl phthalate (DBPH), ortho-nitrophenyloctyl ether (O-NPOE), di-octyl phthalate (DOPH), or di-butyl phosphate (DBP). The validity of sensors in the present work has been examined, and steady and reproducible responses were obtained over the concentration ranges of 7.3 × 10-5 to 1.0 × 10-2, 6.6 × 10-6 to 1.0 × 10-2, 1.0 × 10-5 to 1.0 × 10-2, and 2.0 × 10-5 to 1.0 × 10-2 M for DBPH-, O-NPOE-, DOPH-, and DBP-ondansetron, respectively. The sensors revealed Nernstian gradients of 59.61 ± 0.50, 57.71 ± 0.23, 53.01 ± 0.14, and 53.20 ± 0.35 mV per decade individually with pH ranges of 2.5-5.5 in DBPH and 3.5-5.0 in O-NPOE electrodes, and 4.0-5.5 for both individual DOPH and DBP plasticized film-based sensors. The time responses for the sensors were 30, 32, 31, and 29 s for DBPH-, O-NPOE-, DOPH-, and DBP-ondansetron, respectively. The developed sensors also exhibited high selectivity towards ondansetron hydrochloride against different interfering species of inorganic particles with long-term stability of approximately 41, 36, 18, and multiple days for the DBPH, O-NPOE, DOPH, and DBP electrodes.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Structure of ondansetron hydrochloride.
Fig. 2
Fig. 2. Ion-selective electrodes in an electro-analytical cell.
Fig. 3
Fig. 3. Potentiometric response of ondansetron PVC matrix membrane sensors.
Fig. 4
Fig. 4. FTIR spectrum of (a) ion pair ODH-MPA and (b) pure drug ODH.
Fig. 5
Fig. 5. pH range for ODH electrodes in 10−3 M ondansetron hydrochloride solution.
See this image and copyright information in PMC

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