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Case Reports
. 2022 Mar 28;14(3):e23588.
doi: 10.7759/cureus.23588. eCollection 2022 Mar.

A Collision Tumor in the Breast Consisting of Invasive Ductal Carcinoma and Malignant Melanoma

John Grove  1 , Miglena K Komforti  2 , Laura Craig-Owens  3 , Frank Beuerlein  3
Affiliations
Case Reports

A Collision Tumor in the Breast Consisting of Invasive Ductal Carcinoma and Malignant Melanoma

John Grove et al. Cureus. .

Abstract

Collision tumors are rare neoplasms that consist of at least two different cell lineages at the same site. Given the many possible combinations that can occur, collision tumors, while rare, have been reported in multiple locations such as the stomach, bladder, and thyroid. Collision tumors are rarely found in breast tissue, with only a few cases reported in the literature. We herein report a unique case of a 79-year-old woman with a history of melanoma who presented with a left breast mass that was subsequently found to have invasive ductal carcinoma (IDC) and metastatic melanoma in the breast tissue. This is one of the first reported combinations of these two malignancies.

Keywords: collision tumor; immunohistochemical stain; invasive ductal breast carcinoma; lymphovascular invasion; malignant melanoma metastasis.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Hematoxylin and Eosin staining of collision tumor.
(A) Low power view of breast tissue containing metastatic melanoma (arrow) adjacent to invasive ductal carcinoma (arrowhead). (B) High power view demonstrating the different morphologic presentation of the metastatic melanoma (arrow) and invasive ductal carcinoma (arrowhead).
Figure 2
Figure 2. Immunohistochemical staining of collision tumor.
(A) SOX10 stain of malignant melanoma and (B) pan-melanoma stain of metastatic melanoma.
Figure 3
Figure 3. Positive AE1/AE3 immunohistochemical staining of the invasive ductal carcinoma component (arrows).
The malignant melanoma is immediately adjacent (arrowheads) with no staining.
See this image and copyright information in PMC

References

    1. Epidemiological characteristics of and risk factors for breast cancer in the world. Momenimovahed Z, Salehiniya H. Breast Cancer (Dove Med Press) 2019;11:151–164. - PMC - PubMed
    1. Alkabban FM, Ferguson T. Treasure Island, FL: StatPearls Publishing; 2021. Breast Cancer.
    1. Epidemiology of melanoma. Saginala K, Barsouk A, Aluru JS, Rawla P, Barsouk A. Med Sci (Basel) 2021;9 - PMC - PubMed
    1. A rare collision tumour of infiltrating ductal carcinoma and squamous cell carcinoma of skin overlying breast: a case report. Geetha R, Kalyani R, Srinivas MV, Shakthidasan C. J Clin Diagn Res. 2015;9:0–8. - PMC - PubMed
    1. Collision of three histologically distinct endometrial cancers of the uterus. Jang KS, Lee WM, Kim YJ, Cho SH. J Korean Med Sci. 2012;27:89–92. - PMC - PubMed

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