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. 2022 Apr 2:76:103552.
doi: 10.1016/j.amsu.2022.103552. eCollection 2022 Apr.

Diabetic foot ulcer in Southern Jordan: A cross-sectional Study of Clinical and Microbiological Aspects

Emad Aborajooh  1 , Talal M Alqaisi  2 , Mohammad Yassin  3 , Eyad Alqpelat  4 , Alaa Abofaraj  5 , Tariq Alrawajih  6 , Hamed Alzoubi  7 , Mohammad Abu Lubad  7
Affiliations

Diabetic foot ulcer in Southern Jordan: A cross-sectional Study of Clinical and Microbiological Aspects

Emad Aborajooh et al. Ann Med Surg (Lond). .

Abstract

Background: Diabetes mellitus (DM) is a common metabolic disorder that significantly affects public health. Diabetic foot ulcer (DFU) is one of the serious complications of diabetes. DFU has a wide spectrum of bacterial isolates comprising Gram-positive, Gram-negative, aerobic bacteria and anaerobes. In the last two decades there has been an increase in the multidrug-resistant isolates (MDR).

Materials and methods: This cross-sectional prospective observational study was conducted in southern Jordan among patients with DFU. The included variables are sociodemographic and clinical information. Isolates from swab culture of ulcers and antimicrobial susceptibility pattern are also recorded.

Results: A total of 64 diabetic patients with DFU were included in this study. Most patients included in the study were males with male-to-female ratio of (2.2:1). The mean age was 54 years (SD ± 10.7). The mean duration of DM was 16.4 years (SD ± 7.5) and the mean HbA1c was 9.9% (SD ± 2.1). Neuropathy and anemia were noted in 72% and 44% of patients, respectively. The most frequent bacterial isolates were gram negative bacteria accounts for 29 isolates (45.3%). About 37.5% (24) of bacterial isolates showed MDR pattern. Previous antibiotic use in the last 30 days showed significant association with MDR bacteria (p-value <0.05). Previous history of amputations, presence of neuropathy, renal impairment, retinopathy, presence of anemia, limited joint mobility and presence of foot deformity were significantly associated with Wagner's grade ≥ three.

Conclusion: Many factors affect and increase the risk of having high grade diabetic foot ulcer. The most frequent bacterial isolates from diabetic foot ulcers were gram negative bacteria. High rates of MDR in this study reflect the loose implementation of regulations in Jordan regarding antibiotics dispensing.

Keywords: DFU, Diabetic Foot Ulcer; Diabetes; Diabetic foot ulcer; Jordan; MDR, multidrug-resistant isolates; Multidrug resistance; Wagner's grade.

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Conflict of interest statement

No conflict of interest, financial or otherwise.

Figures

Fig. 1
Fig. 1
Wagner's grade 1 and 2 among patients with diabetic foot ulcer participated in the study.
Fig. 2
Fig. 2
Wagner's grade 3 and 4 among patients with diabetic foot ulcer participated in the study.
Fig. 3
Fig. 3
Isolates among 64 patients with diabetic foot ulcer with percentage of each one.
See this image and copyright information in PMC

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