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Review
. 2022 Mar;11(3):870-878.
doi: 10.4103/jfmpc.jfmpc_2411_20. Epub 2022 Mar 10.

Effects of vitamin D on bone density in healthy children: A systematic review

Pegah Karimian  1 , Hamidreza Khoshnezhad Ebrahimi  2 , Shabahang Jafarnejad  2 , Motahare Aghajani Delavar  1
Affiliations
Review

Effects of vitamin D on bone density in healthy children: A systematic review

Pegah Karimian et al. J Family Med Prim Care. 2022 Mar.

Abstract

Skeletal growth and bone health are very important in children. The effective role of vitamin D in bone mineral density has been observed in children and adolescents. This systematic review study evaluated the effects of vitamin D on bone density in healthy children with the help of valid databases and the website of clinical trials. The results of experimental, clinical, retrospective, prospective, double-blind, and randomized studies were used. Articles that appropriately covered the topic and had the proper content structure were selected for this review. Out of a total of 132 articles, finally, 13 articles were selected based on inclusion and exclusion criteria for further study, the results of which show the association between serum levels of vitamin D and bone mineral density and health. However, in some articles, the relationship between other influential variables such as age and nutrition on bone density in children was identified. In general, the current systematic review demonstrates the role of vitamin D on bone density in healthy children, so that in children studied, vitamin D is at different levels and complications related to bone density are observed in many children. It is recommended that more clinical and longitudinal studies be performed to further understand the role of vitamin D levels in bone health in children.

Keywords: Bone density; children; vitamin D; vitamin D deficiency.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Diagram related to the selection of reviewed articles
See this image and copyright information in PMC

References

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