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. 2022 Apr 13:13:879118.
doi: 10.3389/fphar.2022.879118. eCollection 2022.

Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review

Shimaa M Abdelgawad  1 , Mahmoud A El Hassab  2 , Mohammed A S Abourehab  3 , Eslam B Elkaeed  4 , Wagdy M Eldehna  5   6
Affiliations

Olive Leaves as a Potential Phytotherapy in the Treatment of COVID-19 Disease; A Mini-Review

Shimaa M Abdelgawad et al. Front Pharmacol. .

Abstract

Beginning from December 2019, widespread COVID-19 has caused huge financial misfortunes and exceptional wellbeing emergencies across the globe. Discovering an effective and safe drug candidate for the treatment of COVID-19 and its associated symptoms became an urgent global demand, especially due to restricted information that has been discharged with respect to vaccine efficacy and safety in humans. Reviewing the recent research, olive leaves were selected as a potential co-therapy supplement for the treatment and improvement of clinical manifestations in COVID-19 patients. Olive leaves were reported to be rich in phenolic compounds such as oleuropein, hydroxytyrosol, verbascoside, apigenin-7-O-glucoside, and luteolin-7-O-glucoside and also triterpenoids such as maslinic, ursolic, and oleanolic acids that have been reported as anti-SARS-CoV-2 metabolites in recent computational and in vitro studies. In addition, olive leaf extract was previously reported in several in vivo studies for its anti-inflammatory, analgesic, antipyretic, immunomodulatory, and antithrombotic activities which are of great benefit in the control of associated inflammatory cytokine storm and disseminated intravascular coagulation in COVID-19 patients. In conclusion, the described biological activities of olive leaves alongside their biosafety, availability, and low price make them a potential candidate drug or supplement to control COVID-19 infection and are recommended for clinical investigation.

Keywords: SARS-CoV-2; anti-inflammatory; anti-thrombotic; antiviral; olive leaves; phytoconstituents.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structures of secoiridoids, triterpenoids, and steroids reported in Olea europaea leaves.
FIGURE 2
FIGURE 2
Chemical structures of flavonoids and phenolic compounds reported in Olea europaea leaves.
See this image and copyright information in PMC

References

    1. Alsharif K. F., Almalki A. A., Al-Amer O., Mufti A. H., Theyab A., Lokman M. S., et al. (2020). Oleuropein Protects against Lipopolysaccharide-Induced Sepsis and Alleviates Inflammatory Responses in Mice. IUBMB life 72 (10), 2121–2132. 10.1002/iub.2347 - DOI - PubMed
    1. Alyami M. H., Naser A. Y., Orabi M. A. A., Alwafi H., Alyami H. S. (2020). Epidemiology of COVID-19 in the Kingdom of Saudi Arabia: An Ecological Study. Front. Public Health 8, 506. 10.3389/fpubh.2020.00506 - DOI - PMC - PubMed
    1. Benavente-Garcıa O., Castillo J., Lorente J., Ortuño A., Del Rio J. (2000). Antioxidant Activity of Phenolics Extracted from Olea Europaea L. Leaves. Food Chem. 68 (4), 457–462. 10.1016/S0308-8146(99)00221-6 - DOI
    1. Bianchi G., Murelli C., Vlahov G. (1992). Surface Waxes from Olive Fruits. Phytochemistry 31 (10), 3503–3506. 10.1016/0031-9422(92)83716-c - DOI
    1. Bouaziz M., Grayer R. J., Simmonds M. S., Damak M., Sayadi S. (2005). Identification and Antioxidant Potential of Flavonoids and Low Molecular Weight Phenols in Olive Cultivar Chemlali Growing in Tunisia. J. Agric. Food Chem. 53 (2), 236–241. 10.1021/jf048859d - DOI - PubMed

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