Chronic post-surgical pain - update on incidence, risk factors and preventive treatment options
- PMID: 35496645
- PMCID: PMC9039436
- DOI: 10.1016/j.bjae.2021.11.008
Chronic post-surgical pain - update on incidence, risk factors and preventive treatment options
Keywords: CPSP, chronic post-surgical pain; DN4, Douleur Neuropathique 4 questionnaire; GAD-7, General Anxiety Disorder Questionnaire; ICD-11, International Classification of Diseases, Eleventh Revision; NP, neuropathic pain; PHQ-9, Patient Health Questionnaire; QST, Quantitative Sensory Testing; ROC-AUC, area under the receiver operating characteristic; SF-12, Short Form Health Survey-12; chronic post-surgical pain; perioperative pain; risk factors.
Conflict of interest statement
DCR has no conflicts of interest. EPZ has received financial support to her institution from Mundipharma and Grunenthal for research activities and advisory and lecture fees from Grünenthal, Mundipharma and Novartis.
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References
-
- Schug S.A., Lavand’homme P., Barke A., Korwisi B., Rief W., Treede R.-D. The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain. Pain. 2019;160:45–52. - PubMed
-
- Fletcher D., Stamer U.M., Pogatzki-Zahn E., et al. Chronic postsurgical pain in Europe: an observational study. Eur J Anaesthesiol. 2015;32:725–734. - PubMed
-
- Pogatzki-Zahn E., Segelcke D., Zahn P. Mechanisms of acute and chronic pain after surgery: update from findings in experimental animal models. Curr Opin Anaesthesiol. 2018;31:575–585. - PubMed
-
- Glare P., Aubrey K.R., Myles P.S. Transition from acute to chronic pain after surgery. Lancet. 2019;393:1537–1546. - PubMed
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