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. 2022 Jul:22:100463.
doi: 10.1016/j.bbih.2022.100463. Epub 2022 Apr 23.

Cognitive deficits and memory impairments after COVID-19 (Covishield) vaccination

Bipin Chaurasia  1 , Vishal Chavda  2 , Bingwei Lu  2 , Kanwaljeet Garg  3 , Nicola Montemurro  4
Affiliations

Cognitive deficits and memory impairments after COVID-19 (Covishield) vaccination

Bipin Chaurasia et al. Brain Behav Immun Health. 2022 Jul.

Abstract

Vaccination is an essential public health strategy to control the 2019 Coronavirus (COVID-19) pandemic. While the benefits of the COVID-19 vaccines far outweigh the risks, side effects continue to be reported in the literature. We report a 65-year-old man who developed cognitive deficits and memory impairments following his first dose of Oxford AstraZeneca vaccine (Covishield). The onset of acute cognitive deficits and memory impairments could be another complication to COVID-19 vaccination that physicians and neurologists need to be warned to. Monitoring the safety of COVID-19 vaccines and describing side effects associated with them is essential to improve safety profiles and enhance public trust.

Keywords: COVID-19; Cognitive deficits; Coronavirus; SARS-CoV; Vaccination.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Illustration represents the possible hypothesis and molecular mechanism of memory loss associated with cognitive decline in COVID-19 infection. A: Administration of mRNA vaccines triggers cytokine cycle which communicates with memory T cell. B: Administration of DNA vaccine triggers cytokines leading to Anti-S protein antibodies, B cell and memory B cell. C: It shows the pathological mechanisms of COVID-19 infection in which affected B and T Cell plays a vital role in thrombosis leading to stroke and associated cognitive decline.
See this image and copyright information in PMC

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