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Comment
. 2022 Apr;2(2):19.
doi: 10.20517/jca.2022.08. Epub 2022 Mar 16.

PLA2G7, caloric restriction and cardiovascular aging

Fang Cao  1 , Richard T Lee  1
Affiliations
Comment

PLA2G7, caloric restriction and cardiovascular aging

Fang Cao et al. J Cardiovasc Aging. 2022 Apr.
No abstract available

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Conflict of interest statement

Conflicts of interests Dr. Cao F declared that there are no conflicts of interest. Dr. Lee RT is a co-founder, scientific advisory board member, and private equity holder of Elevian, Inc. Dr. Lee RT is a member of the scientific advisory board of Revidia Therapeutics, Inc, and a consultant to BlueRock Therapeutics.

Figures

Figure 1.
Figure 1.
Prior work suggested a causative role of PLA2G7 in various cardiovascular diseases (right)[4,16]. Spadaro et al.[3] demonstrated caloric restriction reduces PLA2G7 expression and improves immunogenic and metabolic aspects of aging (left). PLA2G7 age-related methylation has been suggested to be a biomarker of cardiovascular aging, though the mechanism is unclear, and PLA2G7 has not been shown to have a causative role in cardiovascular aging[5].
See this image and copyright information in PMC

Comment on

References

    1. Trends G Public health and aging: trends in aging - United States and worldwide. JAMA 2003;289:1371–3. - PubMed
    1. Lakatta EG. Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons. Heart Fail Rev 2002;7:29–49. - PubMed
    1. Spadaro O, Youm Y, Shchukina I, et al. Caloric restriction in humans reveals immunometabolic regulators of health span. Science 2022;375:671–7. - PMC - PubMed
    1. Tellis CC, Tselepis AD. The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma. Biochim Biophys Acta 2009;1791:327–38. - PubMed
    1. Jiang D, Zheng D, Wang L, et al. Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females. PLoS One 2013;8:e59752. - PMC - PubMed

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