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. 1986 Dec 19;383(2):307-16.
doi: 10.1016/s0378-4347(00)83476-3.

High-performance liquid chromatographic analysis of norepinephrine and alpha-methylnorepinephrine in microdissected noradrenergic cell groups of the rabbit brain

C J Oddie, G K Mill, P J Scott, A Bobik

High-performance liquid chromatographic analysis of norepinephrine and alpha-methylnorepinephrine in microdissected noradrenergic cell groups of the rabbit brain

C J Oddie et al. J Chromatogr. .

Abstract

A high-performance liquid chromatographic method with electrochemical detection has been developed to measure norepinephrine (NE) and alpha-methylnorepinephrine (alpha-MeNE) in microdissected noradrenergic cell groups of the rabbit brain stem. The method is shown to be specific, accurate and precise and has a sensitivity of 0.5 pmol per sample. The method has been applied to the measurement of NE and alpha-MeNE levels in the A1, A2, A5, A6 and A7 noradrenergic cell groups after administration of the antihypertensive drug alpha-methyldopa (alpha-MD), so that the sites of action of alpha-MD within the central nervous system may be localised.

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