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. 2022 Apr 13:17:100316.
doi: 10.1016/j.lrr.2022.100316. eCollection 2022.

Observations on hematogones with light chain restriction

Angela D'Ardia  1 , Valeria Ciliberti  1 , Pio Zeppa  1 , Alessandro Caputo  1
Affiliations

Observations on hematogones with light chain restriction

Angela D'Ardia et al. Leuk Res Rep. .

Abstract

Light-chain restricted hematogones (LCR HGs) detected by flow cytometry (FC) may, occur in bone marrow mimicking involvement by a B-cell lymphoma. This phenomenon can present a diagnostic pitfall and negatively impact patient management, and may occur in other organs, including lymph nodes, For this reason, it is recommended to utilize, in case of LCR in lymph node, one additional morphological, phenotypical or molecular criteria for the diagnosis of lymphoma on cytological samples.

Keywords: Light chain restriction; Reactive processes.

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Conflict of interest statement

All authors do not have any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work

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