Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Mar;15(3):685-693.
doi: 10.14202/vetworld.2022.685-693. Epub 2022 Mar 24.

The application of ascorbic acid as a therapeutic feed additive to boost immunity and antioxidant activity of poultry in heat stress environment

Affiliations
Review

The application of ascorbic acid as a therapeutic feed additive to boost immunity and antioxidant activity of poultry in heat stress environment

Truong Van Hieu et al. Vet World. 2022 Mar.

Abstract

Ascorbic acid, widely known as vtamin C, is an essential nutrient for animals such as poultry. Ascorbic acid in poultry feed improves animal health and thus increases the growth performance of birds. Ascorbic acid can be used in the form of synthetic products or can be naturally obtained from fruits and plants. It is soluble in water and can be easily administered in drinking water and the diet. Poultry can synthesize ascorbic acid in the body. However, the performance of the animals can be improved by adding ascorbic acid to their diet. In addition, ascorbic acid is called an antioxidant and an anti-inflammatory. This increases their resistance to disease during the transition season. Ascorbic acid supplementation positively affects the stress response, especially during the dry season in tropical countries. Furthermore, supplementing ascorbic acid in the poultry's diet improves resistance to diseases, regulates stress, and helps in the body's oxidation process. Ultimately, this enhances the laying rate, egg hatch performance, and higher poultry productivity. For layers at the end of the laying period, it helps increase the quality of the eggshell and reduces the proportion of broken eggs. Ascorbic acid has a strong relationship with other vitamins such as vitamin E and other substances such as zinc, safflower oil, folic acid, and a fibrous diet. This review aims to synthesize all the information of ascorbic acid in the poultry's diet, thereby providing the general role of ascorbic acid for the poultry industry.

Keywords: antioxidant; ascorbic acid; immune system; poultry production.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure-1
Figure-1
The pathway of ascorbic acid [26].
Figure-2
Figure-2
The temperature between zones in poultry production [66].

References

    1. National Center for Biotechnology Information. 2021. [Last accessed on 2021 Oct 10]. Available from: https://www.pubchem.ncbi.nlm.nih.gov/compound/Ascorbic-acid .
    1. El-Senousey H.K, Chen B, Wang J.Y, Atta A.M, Mohamed F.R, Nie Q.H. Effects of dietary vitamin C, vitamin E, and alpha-lipoic acid supplementation on the antioxidant defense system and immune-related gene expression in broilers exposed to oxidative stress by dexamethasone. Poul. Sci. 2018;97(1):30–38. - PubMed
    1. Whitehead C.C, Keller T. An update on ascorbic acid in poultry. Worlds Poul. Sci. J. 2003;59(2):161–184.
    1. Shewita R.S, El-Naggar K, El-Naby W.S.A. Influence of dietary vitamin C on growth performance, blood biochemical parameters and transcript levels of heat shock proteins in high stocking density reared broiler chickens. Slov. Vet. Res. 2019;56(22):129–138.
    1. Ahmadu S, Mohammed A.A, Buhari H, Auwal A. An overview of vitamin C as an antistress in poultry. Malays. J. Vet. Res. 2016;7(2):9–22.

LinkOut - more resources