Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 14:9:839875.
doi: 10.3389/fcvm.2022.839875. eCollection 2022.

Comparison of Risk of Target Organ Damage in Different Phenotypes of Arterial Stiffness and Central Aortic Blood Pressure

Yaya Bai  1 , Qian Wang  1 , Di Cheng  1 , Yueliang Hu  1 , Huijuan Chao  1 , Alberto Avolio  2 , Biwen Tang  1 , Junli Zuo  1   2
Affiliations

Comparison of Risk of Target Organ Damage in Different Phenotypes of Arterial Stiffness and Central Aortic Blood Pressure

Yaya Bai et al. Front Cardiovasc Med. .

Abstract

Objectives: The aim of this study was to explore the risk of target organ damage (TOD) in different groups based on carotid-femoral pulse wave velocity (cfPWV) and central aortic blood pressure (CBP) in different populations.

Methods: The study cohort was divided into four groups according to the status of cfPWV and CBP [Group (cfPWV/CBP): high cfPWV and high CBP; Group (cfPWV): high cfPWV and normal CBP; Group (CBP): normal cfPWV and high CBP; Group (control): normal cfPWV and normal CBP]. TOD was determined by the assessment of carotid intima-media thickness (CIMT) abnormality, chronic kidney disease (CKD), microalbuminuria, and left ventricular hypertrophy (LVH).

Results: A total of 1,280 patients (mean age 53.14 ± 12.76 years, 64.1% male patients) were recruited in this study. Regarding Group (control) as reference, LVH was significantly higher in Group (cfPWV) and Group (CBP) [OR 2.406, 95% CI (1.301-4.452), P < 0.05; OR 2.007, 95% CI (1.335-3.017), P < 0.05]; microalbuminuria was significantly higher in Group (cfPWV/CBP) and Group (CBP) [OR 3.219, 95% CI (1.630-6.359), P < 0.05; OR 3.156, 95% CI (1.961-5.079), P < 0.05]. With age stratified by 60 years, the risk of CKD was significantly higher in Group (cfPWV/CBP) [OR 4.019, 95% CI (1.439-11.229), P < 0.05].

Conclusion: Different phenotypes based on the status of cfPWV and CBP were associated with different TOD. Individuals with both cfPWV and CBP elevated have a higher risk of microalbuminuria.

Keywords: arterial stiffness; carotid-femoral pulse wave velocity; central blood pressure; risk factors; target organ damage.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Correlations between target organ damage (TOD) and carotid-femoral pulse wave velocity (cfPWV), as well as central systolic blood pressure (cSBP), carotid intima-media thickness (CIMT), and cfPWV (A); CIMT and cSBP (B); estimated glomerular filtration rate (eGFR) and cfPWV (C); eGFR and cSBP (D); left ventricular mass index (LVMI) and cfPWV (E); LVMI and cSBP (F); Log (urinary albumin-creatinine ratio, ACR) (LogACR) and cfPWV (G); and LogACR and cSBP (H). Linear regression lines for (x) and (y) variables are shown with correlation coefficients and P-values.
Figure 2
Figure 2
Multiple stepwise logistic regression of target organ damage among groups by cf-PWV and CBP without adjusted factors. Groups by cfPWV and CBP status: Group (cfPWV/CBP): high cfPWV and high CBP; Group (cfPWV): high cfPWV and normal CBP; Group (CBP): normal cfPWV and high CBP; Group (control): normal cfPWV and normal CBP.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Cheng S, et al. . Relations of central hemodynamics and aortic stiffness with left ventricular structure and function: the Framingham heart study. J Am Heart Assoc. (2016) 5: e002693. 10.1161/JAHA.115.002693 - DOI - PMC - PubMed
    1. Kollias A, Lagou S, Zeniodi ME, Boubouchairopoulou N, Stergiou GS. Association of central vs. brachial blood pressure with target-organ damage: systematic review and meta-analysis. Hypertension. (2016) 67: 183–90. 10.1161/HYPERTENSIONAHA.115.06066 - DOI - PubMed
    1. Lu Y, Zhu M, Bai B, Chi C, Yu S, Teliewubai J, et al. . Comparison of carotid-femoral and brachial-ankle pulse-wave velocity in association with target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai study. J Am Heart Assoc. (2017) 6:e004168. 10.1161/JAHA.116.004168 - DOI - PMC - PubMed
    1. Vasan RS, Short MI, Niiranen TJ, Xanthakis V, DeCarli C, Cheng S, et al. . Interrelations between arterial stiffness, target organ damage, and cardiovascular disease outcomes. J Am Heart Assoc. (2019) 8:e012141. 10.1161/JAHA.119.012141 - DOI - PMC - PubMed
    1. Zuo J, Chang G, Tan I, Butlin M, Chu SL, Avolio A. Central aortic pressure improves prediction of cardiovascular events compared to peripheral blood pressure in short-term follow-up of a hypertensive cohort. Clin Exp Hypertens. (2020) 42:16–23. 10.1080/10641963.2018.1557682 - DOI - PubMed

LinkOut - more resources